Publication Name	World Journal of Gastroenterology
Manuscript ID	5549
Country	China

Received	2013-09-14 09:23
Peer-Review Started	2013-09-14 19:53
First Decision by Editorial Office Director
Return for Revision	2013-10-31 10:41
Revised	2013-11-08 09:36
Publication Fee Transferred
Second Decision by Editor	2014-02-20 08:57
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-02-20 09:41
Articles in Press
Edit the Manuscript by Language Editor	2014-03-17 14:12
Typeset the Manuscript	2014-03-31 15:24
Publish the Manuscript Online	2014-04-14 10:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Epithelial membrane protein 1 negatively regulates cell growth and metastasis in colorectal carcinoma
Manuscript Source	Invited Manuscript
All Author List	Guo-Gui Sun, Ya-Di Wang, Da-Wei Cui, Yun-Jie Cheng and Wan-Ning Hu
Funding Agency and Grant Number
Corresponding Author	Dr. Wan-Ning Hu, Department of Chemoradiotherapy, Tangshan People’s Hospital, No. 65, Shengli Road, Lunan District, Tangshan 063000, Hebei Province, China. wanning_hu2008@sina.com
Key Words	Epithelial membrane protein 1; Colorectal carcinoma; Caspase-9; Vascular endothelial growth factor C; Prognosis
Core Tip	Epithelial membrane protein 1 (EMP1) has a known role in tumor development and progression, and its activity is linked to a number of biological processes including proliferation, apoptosis, invasion, and metastasis of colorectal cancer. We detected expression of EMP1 in colorectal carcinoma and analyzed the biological effect of EMP1 overexpression in a colorectal carcinoma cell line. EMP1 expression was decreased in colorectal cancer and its expression correlated significantly with T stage, lymph node metastasis, clinic stage, histological grade, and poor overall survival. Taken together, our findings suggest that EMP1 may play an important role as a negative regulator of colorectal cancer.
Publish Date	2014-04-14 10:49
Citation	Sun GG, Wang YD, Cui DW, Cheng YJ, Hu WN. Epithelial membrane protein 1 negatively regulates cell growth and metastasis in colorectal carcinoma. World J Gastroenterol 2014; 20(14): 4001-4010
URL	http://www.wjgnet.com/1007-9327/full/v20/i14/4001.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i14.4001

Full Article (PDF)	WJG-20-4001.pdf
Full Article (Word)	WJG-20-4001.doc
Manuscript File	5549-Review.doc
Answering Reviewers	5549-Answering reviewers.pdf
Copyright License Agreement	5549-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5549-Language certificate.pdf
Peer-review Report	5549-Peer review(s).pdf
Scientific Editor Work List	5549-Scientific editor work list.doc