Publication Name	World Journal of Diabetes
Manuscript ID	55490
Country	Spain

Received	2020-03-20 12:00
Peer-Review Started	2020-03-20 12:02
To Make the First Decision
Return for Revision	2020-04-26 21:45
Revised	2020-05-27 04:57
Second Decision	2020-06-11 08:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-06-14 19:08
Articles in Press	2020-06-14 19:08
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-06-28 07:52
Typeset the Manuscript	2020-08-04 03:12
Publish the Manuscript Online	2020-08-14 00:58

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Range of adiposity and cardiorenal syndrome
Manuscript Source	Invited Manuscript
All Author List	Fernando Pazos
ORCID	Author(s) ORCID Number Fernando Pazos http://orcid.org/0000-0002-6987-3569
Funding Agency and Grant Number
Corresponding Author	Fernando Pazos, MD, PhD, Associate Professor, Department of Medicine, Medicine Faculty, Cantabria University, Valdecilla Hospital, PO box 2257, Santander 39080, Cantabria, Spain. fernandoantonio.pazos@scsalud.es
Key Words	Obesity; Morbid obesity; Cardiorenal syndrome; Heart failure; Chronic kidney disease;
Core Tip	Visceral adiposity and morbid obesity are risks of heart and kidney disease, configuring a cardiorenal syndrome. Adipose tissue resulted in hemodynamic and mechanic derangements besides turning on neuro-humoral systems such as endothelial dysfunction, adipokines, renin-angiotensin-aldosterone, sympathetic nervous system, natriuretic peptides, inflammation, and oxidative stress. Obesity induces cardiac remodeling and fibrosis, leading to heart failure (HF). HF with preserved ejection fraction is characteristically linked to obesity. Hyperfiltration, increased glomerular capillary wall tension, podocyte dysfunction, and, finally, chronic kidney disease has linked to obesity. Most of the new treatments for diabetes mellitus type 2, which have favorable cardiovascular outcomes, improve the cardiometabolic renal syndrome associated with obesity.
Publish Date	2020-08-14 00:58
Citation	Pazos F. Range of adiposity and cardiorenal syndrome. World J Diabetes 2020; 11(8): 322-350
URL	https://www.wjgnet.com/1948-9358/full/v11/i8/322.htm
DOI	https://dx.doi.org/10.4239/wjd.v11.i8.322

Full Article (PDF)	WJD-11-322.pdf
Full Article (Word)	WJD-11-322.docx
Manuscript File	55490-Review-Webster J.docx
Answering Reviewers	55490-Answering reviewers.pdf
Audio Core Tip	55490-Audio core tip.MP3
Conflict-of-Interest Disclosure Form	55490-Conflict-of-interest statement.pdf
Copyright License Agreement	55490-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	55490-Language certificate.pdf
Peer-review Report	55490-Peer-review(s).pdf
Scientific Misconduct Check	55490-Google-Ma RY-2.png
Scientific Misconduct Check	55490-Scientific misconduct check.pdf
Scientific Editor Work List	55490-Scientific editor work list.pdf
CrossCheck Report	55490-CrossCheck report.pdf