Publication Name	World Journal of Gastroenterology
Manuscript ID	5552
Country	United States

Received	2013-09-14 10:22
Peer-Review Started	2013-09-15 16:12
To Make the First Decision	2013-10-22 16:10
Return for Revision	2013-10-23 19:06
Revised	2013-10-25 22:43
Second Decision	2013-11-29 10:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-29 23:49
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-06 15:48
Publish the Manuscript Online	2014-01-19 14:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Then and now: The progress in hepatitis B treatment over the past 20 years
Manuscript Source	Invited Manuscript
All Author List	Dina Halegoua-De Marzio and Hie-Won Hann
Funding Agency and Grant Number
Corresponding Author	Hie-Won Hann, MD, Liver Disease Prevention Center, Division of Gastroenterology and Hepatology, Thomas Jefferson University Hospital, 1025 Walnut Street, Philadelphia, PA 19107, United States. hie-won.hann@jefferson.edu
Key Words	Chronic hepatitis B; Treatment of hepatitis B; Hepatocellular carcinoma; Nucleoside analogues; Nucleotide analogues
Core Tip	Chronic hepatitis B virus (HBV) infection is one of the leading causes of death across the world due to its worldwide distribution and potential sequelae. Advances in knowledge in combination with the development of potent and effective antiviral therapy for chronic hepatitis B have led to decreased complications from the virus. Timely use of nucleotide/nucleosides may improve liver function and increase survival in patients with hepatic decompensation. Maintained suppression of HBV replication with antiviral therapy halts the progression of liver disease, may reverse liver fibrosis, and can reduce the development of cirrhosis and hepatocellular carcinoma.
Publish Date	2014-01-19 14:17
Citation	Halegoua-De Marzio D, Hann HW. Then and now: The progress in hepatitis B treatment over the past 20 years. World J Gastroenterol 2014; 20(2): 401-413
URL	http://www.wjgnet.com/1007-9327/full/v20/i2/401.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i2.401

Full Article (PDF)	WJG-20-401.pdf
Full Article (Word)	WJG-20-401.doc
Manuscript File	5552-Review.doc
Answering Reviewers	5552-Answering reviewers.pdf
Copyright License Agreement	5552-Copyright assignment.pdf
Peer-review Report	5552-Peer review(s).pdf
Scientific Editor Work List	5552-Scientific editor work list.doc