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Articles Published Processes
8/18/2020 2:09:47 AM | Browse: 763 | Download: 1331
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Received |
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2020-03-21 22:50 |
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Peer-Review Started |
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2020-03-21 22:51 |
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To Make the First Decision |
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Return for Revision |
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2020-05-05 18:51 |
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Revised |
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2020-05-19 21:25 |
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Second Decision |
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2020-07-17 10:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-07-19 21:25 |
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Articles in Press |
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2020-07-19 21:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-07-30 07:19 |
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Publish the Manuscript Online |
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2020-08-18 02:09 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Review |
| Article Title |
Sympathetic nervous system activation and heart failure: Current state of evidence and the pathophysiology in the light of novel biomarkers
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Josip Anđelo Borovac, Domenico D'Amario, Josko Bozic and Duska Glavas |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Josip Anđelo Borovac, BSc, MD, PhD, Associate Research Scientist, Doctor, Doctor, Department of Pathophysiology, University of Split School of Medicine, Soltanska 2, Split 21000, Croatia. jborovac@mefst.hr |
| Key Words |
Autonomic nervous system; Biomarkers; Catecholamines; Catestatin; Chromaffin system; Epinephrine |
| Core Tip |
Sympathetic nervous system activation is one of the key neurohumoral mechanisms that are operative in heart failure and is robustly associated with adverse myocardial remodeling, arrhythmias, sudden cardiac death, and overall poor prognosis in this population. Therefore, adequate diagnosis and quantification of the degree of upregulated sympathetic nervous system activity must be assessed by the clinician in every heart failure patient. A special emphasis must be put on adequate treatment by neurohumoral antagonists such as beta-blockers that will mitigate these adverse effects and improve outcomes. The adjunct use of advanced imaging methods and novel biomarkers might aid in clinical decision-making. |
| Publish Date |
2020-08-18 02:09 |
| Citation |
Borovac JA, D'Amario D, Bozic J, Glavas D. Sympathetic nervous system activation and heart failure: Current state of evidence and the pathophysiology in the light of novel biomarkers. World J Cardiol 2020; 12(8): 373-408 |
| URL |
https://www.wjgnet.com/1949-8462/full/v12/i8/373.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v12.i8.373 |
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