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Articles Published Processes
9/24/2020 6:20:22 AM | Browse: 885 | Download: 2951
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Received |
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2020-04-01 07:13 |
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Peer-Review Started |
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2020-04-01 07:21 |
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To Make the First Decision |
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Return for Revision |
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2020-06-04 03:29 |
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Revised |
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2020-06-11 01:14 |
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Second Decision |
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2020-08-24 10:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-08-25 22:46 |
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Articles in Press |
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2020-08-25 22:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-09-07 02:21 |
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Typeset the Manuscript |
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2020-09-23 02:16 |
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Publish the Manuscript Online |
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2020-09-24 06:20 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Granulocyte-macrophage colony-stimulating factor protects mice against hepatocellular carcinoma by ameliorating intestinal dysbiosis and attenuating inflammation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yong-Na Wu, Lei Zhang, Tuo Chen, Xun Li, Li-Hong He and Guang-Xiu Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
3770536 |
| National Natural Science Foundation of China |
31960236 |
| Lanzhou Talent Innovation and Entrepreneurship Project |
2019-RC-34 |
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| Corresponding Author |
Guang-Xiu Liu, PhD, Chairman, Research Scientist, Key Laboratory of Desert and Desertification, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, No. 320 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. gpwzq0130@126.com |
| Key Words |
Granulocyte-macrophage colony-stimulating factor; Microbiome; Inflammation; Hepatocellular carcinoma; ; |
| Core Tip |
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a critical factor in promoting intestinal immunity homeostasis. Whether GM-CSF plays a protective role on hepatocellular carcinoma (HCC) by regulating immunity and intestinal microecology is not completely understood. The orthotopic transplantation tumor models of hepatocellular carcinoma were established on mice by using lentiviral transfected human GM-CSF sequence into human HCC cell line. And our study obtained measurements of the absolute abundance of specific fecal bacterial communities via absolute quantification 16S rRNA amplicon sequencing technology. And this study provides new insights for therapeutic approaches to treat HCC. |
| Publish Date |
2020-09-24 06:20 |
| Citation |
Wu YN, Zhang L, Chen T, Li X, He LH, Liu GX. Granulocyte-macrophage colony-stimulating factor protects mice against hepatocellular carcinoma by ameliorating intestinal dysbiosis and attenuating inflammation. World J Gastroenterol 2020; 26(36): 5420-5436 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i36/5420.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i36.5420 |
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