| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Basic Study |
| Article Title |
6-gingerol protects nucleus pulposus-derived mesenchymal stem cells from oxidative injury by activating autophagy
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Li-ping Nan, Feng Wang, Yang Liu, Zhong Wu, Xin-Min Feng, Jun-Jian Liu and Liang Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The National Natural Science Foundation of China |
81972136 |
| National Natural Science Foundation for Young Scholars of China |
81401830 |
| Guangxi natural science foundation general project |
2018JJA14775 |
| Young Medical Scholars Major Program of Jiangsu Province |
QNRC2016342 |
| Innovation Team Project of Jiangsu Province |
CXTDB2017004 |
| Key Funding Project of Maternal and Child Health Research of Jiangsu Province |
F201801 |
|
| Corresponding Author |
Liang Zhang, MD, PhD, Academic Research, Assistant Professor, Associate Chief Physician, Chief Doctor, Doctor, Doctor, Research Scientist, Surgeon, Teacher, Department of Orthopedics, Clinical Medical College of Yangzhou University, No. 98 Nantong West Road, Yangzhou 225001, Jiangsu Province, China. zhangliang6320@sina.com |
| Key Words |
Nucleus pulposus-derived mesenchymal stem cells; 6-Gingerol; Intervertebral disc degeneration; Oxidative stress; Autophagy; Apoptosis |
| Core Tip |
To date, there has been no effective treatment for intervertebral disc degeneration (IDD). Nucleus pulposus-derived mesenchymal stem cells (NPMSCs) showed encouraging results in IDD treatment, but the overexpression of reactive oxygen species (ROS) impaired the endogenous repair abilities of NPMSCs. The 6-gingerol (6-GIN) efficiently decreased ROS levels, attenuated hydrogen peroxide-induced NPMSC apoptosis and protected the ECM from degeneration. 6-GIN is a promising candidate for treating IDD. |
| Publish Date |
2020-12-27 05:30 |
| Citation |
Nan LP, Wang F, Liu Y, Wu Z, Feng XM, Liu JJ, Zhang L. 6-gingerol protects nucleus pulposus-derived mesenchymal stem cells from oxidative injury by activating autophagy. World J Stem Cells 2020; 12(12): 1603-1622 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i12/1603.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i12.1603 |
