Publication Name	World Journal of Gastroenterology
Manuscript ID	5584
Country	China

Received	2013-09-16 10:24
Peer-Review Started	2013-09-21 10:38
To Make the First Decision	2013-10-22 16:22
Return for Revision	2013-10-28 14:07
Revised	2013-10-29 12:49
Second Decision	2013-11-18 20:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-19 12:00
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-12-01 11:55
Typeset the Manuscript	2013-12-26 21:05
Publish the Manuscript Online	2014-01-20 17:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Epithelial-mesenchymal transition in colorectal cancer tissue of patients with Lynch syndrome
Manuscript Source	Invited Manuscript
All Author List	Guo-Li Gu, Xiao-Quan Zhu, Xue-Ming Wei, Li Ren, De-Chang Li and Shi-Lin Wang
Funding Agency and Grant Number	Funding Agency Grant Number Capital Citizen Health Cultivation Project Z131100004013021 General Projects of the Chinese PLA “Twelfth Five-Year” Logistics Research Subject CWS11J193
Corresponding Author	Xue-Ming Wei, Professor, Department of General Surgery, the Air Force General Hospital PLA, No.30, Fucheng Road, Haidian District, Beijing 100142, China. kzggl@163.com
Key Words	Lynch syndrome; Mutation; Epithelial-mesenchymal transition; β-catenin; Mismatch repair gene
Core Tip	As a subgroup of colorectal carcinoma (CRC), Lynch syndrome presents better prognosis than sporadic CRC for less invasion and metastasis. Our study found epithelial-mesenchymal transition may play an important role in the development and progression of Lynch syndrome. Lynch syndrome was caused by the mutations of mismatch repair genes, which also beget the mutational inactivation of transforming growth factor-β type Ⅱ receptor. Therefore, the colorectal cancer of Lynch syndrome can escape the inhibitory effect of transforming growth factor-β type 1 (TGFβ1). However TGFβ1 can up-regulate the expression of matrix metalloproteinase-7 and down-regulate the expression of tissue inhibitor of metalloproteinase-2 in tumors by disassembling the E-cadherin/β-catenin complex in the cytomembrane.
Publish Date	2014-01-20 17:10
Citation	Gu GL, Zhu XQ, Wei XM, Ren L, Li DC, Wang SL. Epithelial-mesenchymal transition in colorectal cancer tissue of patients with Lynch syndrome. World J Gastroenterol 2014; 20(1): 250-257
URL	http://www.wjgnet.com/1007-9327/full/v20/i1/250.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i1.250

Full Article (PDF)	WJG-20-250.pdf
Full Article (Word)	WJG-20-250.doc
Manuscript File	5584-Review.doc
Answering Reviewers	5584-Answering reviewers.pdf
Copyright License Agreement	5584-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5584-Language certificate.pdf
Peer-review Report	5584-Peer review(s).pdf
Scientific Editor Work List	5584-Language certificate.pdf