| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Randomized trial of iron depletion in patients with nonalcoholic fatty liver disease and hyperferritinemia
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Luca Valenti, Anna Ludovica Fracanzani, Paola Dongiovanni, Serena Rovida, Raffaela Rametta, Erika Fatta, Edoardo Alessandro Pulixi, Marco Maggioni and Silvia Fargion |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Associazione Malattie Metaboliche del Fegato ONLUS (Non-profit organization for the Study and Care of Metabolic Liver Diseases), Centro Studi Malattie Metaboliche del Fegato, Università degli Studi di Milano |
|
|
| Corresponding Author |
Luca Valenti, MD, Department of Pathophysiology and Transplantation, Metabolic Liver Diseases Research Center, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Policlinico, via F Sforza 35, 20122, Milano, Italy. luca.valenti@unimi.it |
| Key Words |
Ferritin; Randomized controlled trial; Iron depletion; Nonalcoholic fatty liver disease |
| Core Tip |
We compared in a randomized controlled trial iron depletion by phlebotomy (n = 21) to standard therapy (n = 17) in patients with severe nonalcoholic fatty liver disease and hyperferritinemia despite at least 6 mo of lifestyle changes. Phlebotomy was associated with normalization of iron parameters without adverse events. In the 21 patients compliant to the study protocol, the rate of histological improvement was higher in iron depleted vs control subjects (P = 0.039). In patients followed-up at two years (n = 35), by the end of the study alanine aminotransferases, aspartate aminotransferase, and gamma-glutamyl-transferases levels were lower in iron-depleted than in control patients (P < 0.05). |
| Publish Date |
2014-03-18 14:14 |
| Citation |
Valenti L, Fracanzani AL, Dongiovanni P, Rovida S, Rametta R, Fatta E, Pulixi EA, Maggioni M, Fargion S. A randomized trial of iron depletion in patients with nonalcoholic fatty liver disease and hyperferritinemia. World J Gastroenterol 2014; 20(11): 3002-3010 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i11/3002.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i11.3002 |
