| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Promising xenograft animal model recapitulating the features of human pancreatic cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin-Xin Miao, Jian-Yao Wang, Hao-Ze Li, Hao-Ran Guo, Louisa S Chard Dunmall, Zhong-Xian Zhang, Zhen-Guo Cheng, Dong-Ling Gao, Jian-Zeng Dong, Zhong-De Wang and Yao-He Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The National Key R&D Program of China |
2016YFE0200800 |
| Nature Sciences Foundation of China |
81771776 |
| Nature Sciences Foundation of China |
U1704282 |
| Medical Research of Council |
MR/M015696/1 |
|
| Corresponding Author |
Yao-He Wang, MD, PhD, Professor, Sino-British Research Centre for Molecular Oncology, National Centre for International Research in Cell and Gene Therapy, Academy of Medical Sciences, Zhengzhou University, NO. 100 Kexue Roud, Zhengzhou 450000, Henan Province, China. yaohe.wang@qmul.ac.uk |
| Key Words |
Pancreatic cancer; Xenotrans plantation; Syrian hamster; IL-2 receptor gamma gene; Metastasis; Animal model |
| Core Tip |
Xenograft cell transplantation into immune-deficient mice has become the gold standard for assessing tumor progression and efficacy of cancer drugs. However, xenografting human pancreatic cancer (PC) models in nude mice rarely results in development of metastasis and thus does not accurately reflect tumor progression as seen in the human disease. Here we created a new immuno-deficient Syrian hamster with interleukin 2 receptor subunit gamma (IL2RG) gene knockout and demonstrated that the IL2RG-/- Syrian hamster is a promising animal model that can faithfully recapitulate most features of human PC, especially the multiple sites of metastasis. Furthermore, this model can present other key features of human PC, such as stromal reaction and the communication between stromal cells and PC cells. |
| Publish Date |
2020-08-28 15:06 |
| Citation |
Miao JX, Wang JY, Li HZ, Guo HR, Chard Dunmall LS, Zhang ZX, Cheng ZG, Gao DL, Dong JZ, Wang ZD, Wang YH. Promising xenograft animal model recapitulating the features of human pancreatic cancer. World J Gastroenterol 2020; 26(32): 4802-4816 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i32/4802.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i32.4802 |
