Publication Name	World Journal of Gastroenterology
Manuscript ID	5595
Country	China

Received	2013-09-16 13:30
Peer-Review Started	2013-09-16 17:27
To Make the First Decision	2013-09-27 16:28
Return for Revision	2013-09-30 11:59
Revised	2013-10-24 11:08
Second Decision	2014-01-06 17:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-06 19:08
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-01-23 17:46
Typeset the Manuscript	2014-03-05 09:42
Publish the Manuscript Online	2014-03-18 14:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Midkine promotes perineural invasion in human pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Jun Yao, Wen-Yao Li, Shuo-Guo Li, Xiao-Shan Feng and She-Gan Gao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China U1204819 Health Science and Technology Innovation Talents Program of Henan Province 4203
Corresponding Author	Xiao-Shan Feng, PhD, MD, Professor, Department of Oncology, First Affiliated Hospital, Henan University of Science and Technology, King Wah Road 24, Luoyang 471003, Henan Province, China. yaojun74@163.com
Key Words	Midkine; Syndecan-3; Pancreatic cancer; Neurite growth; Perineural invasion
Core Tip	Midkine (MK) has diverse biological properties, including neuritis outgrowth and tumor progression. Syndecan-3 is a high-affinity receptor for MK and an essential component for neurite outgrowths. MK and its receptor may play an important role during perineural invasion. In this study, MK and syndecan-3 proteins levels were detected and analyzed for correlations with clinicopathological features, perineural invasion, and prognosis. Our results show that high expression of MK contributes to the highly perineural invasion and poor prognosis of human pancreatic cancer.
Publish Date	2014-03-18 14:14
Citation	Yao J, Li WY, Li SG, Feng XS, Gao SG. Midkine promotes perineural invasion in human pancreatic cancer. World J Gastroenterol 2014; 20(11): 3018-3024
URL	http://www.wjgnet.com/1007-9327/full/v20/i11/3018.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i11.3018

Full Article (PDF)	WJG-20-3018.pdf
Full Article (Word)	WJG-20-3018.doc
Manuscript File	5595-Review.doc
Answering Reviewers	5595-Answering reviewers.pdf
Copyright License Agreement	5595-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5595-Language certificate.pdf
Peer-review Report	5595-Peer reviewer(s).pdf
Scientific Editor Work List	5595-Scientific editor work list.doc