Publication Name	World Journal of Gastroenterology
Manuscript ID	5597
Country	China

Received	2013-09-16 13:44
Peer-Review Started	2013-09-16 17:50
To Make the First Decision	2013-12-04 09:20
Return for Revision	2013-12-05 09:55
Revised	2014-03-09 20:17
Second Decision	2014-04-16 11:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-16 12:06
Articles in Press	2014-05-23 09:19
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-14 08:30
Typeset the Manuscript	2014-06-22 10:56
Publish the Manuscript Online	2014-07-03 15:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Clinical Trials Study
Article Title	Inhibition of Girdin enhances chemosensitivity of colorectal cancer cells to oxaliplatin
Manuscript Source	Invited Manuscript
All Author List	Ya-Jie Zhang, A-Jian Li, Yi Han, Lu Yin and Mou-Bin Lin
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81272480/H1609
Corresponding Author	Mou-Bin Lin, PhD, Department of General Surgery, RuiJin Hospital Affiliated Shanghai Jiaotong University School of Medicine, No. 197, Ruijin No. 2 Road, Shanghai 200025, China. lmbin@hotmail.com
Key Words	Oxaliplatin; Chemosensitivity; Girdin; Colorectal cancer; TOP2B
Core Tip	The chemoresistance to oxaliplatin is a major problem in the treatment of colorectal cancer (CRC). In this study, a lentivirus-mediated shRNA was constructed to investigate the role of Girdin, a potential regulator of chemotherapy sensitivity. We found that Girdin knockdown enhanced chemosensitivity of colorectal cells to oxaliplatin via reduction of TOP2B. This suggested that Girdin is a modulator of CRC chemoresistance and a potential therapeutic target.
Publish Date	2014-07-03 15:30
Citation	Zhang YJ, Li AJ, Han Y, Yin L, Lin MB. Inhibition of Girdin enhances chemosensitivity of colorectal cancer cells to oxaliplatin. World J Gastroenterol 2014; 20(25): 8229-8236
URL	http://www.wjgnet.com/1007-9327/full/v20/i25/8229.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i25.8229

Full Article (PDF)	WJG-20-8229.pdf
Full Article (Word)	WJG-20-8229.doc
Manuscript File	5597-Review.doc
Answering Reviewers	5597-Answering reviewers.pdf
Copyright License Agreement	5597-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5597-Language certificate.pdf
Peer-review Report	5597-Peer review.pdf
Scientific Editor Work List	5597-Scientific editor work list.doc