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Articles Published Processes
7/28/2020 2:46:56 PM | Browse: 613 | Download: 849
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Received |
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2020-04-21 19:29 |
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Peer-Review Started |
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2020-04-21 19:29 |
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To Make the First Decision |
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Return for Revision |
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2020-06-04 03:45 |
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Revised |
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2020-07-08 20:05 |
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Second Decision |
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2020-07-15 13:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-07-16 01:52 |
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Articles in Press |
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2020-07-16 01:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-07-28 07:23 |
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Publish the Manuscript Online |
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2020-07-28 14:46 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Pancreatic neuroendocrine tumors: Therapeutic challenges and research limitations
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Gabriel Benyomo Mpilla, Philip Agop Philip, Bassel El-Rayes and Asfar Sohail Azmi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIH |
R01 CA240607-01A1 |
| SKY Foundation Inc |
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| Corresponding Author |
Asfar Sohail Azmi, PhD, Assistant Professor, Department of Oncology, Wayne State University School of Medicine, Karmanos Cancer Institute, 4100 John R, HWCRC 732, Detroit, MI 48201, United States. azmia@karmanos.org |
| Key Words |
Pancreatic neuroendocrine tumors; Gastroenteropancreatic neuroendocrine tumors; Management; Limitation; Novel Agents; Emerging targets |
| Core Tip |
Pancreatic Neuroendocrine Tumors (PNETs) can cause severe morbidity due to excessive hormones production and overall tumor mass. The majority of approved therapeutic options in PNETs lack objective response suggesting that there is still a void in the understanding of the biology of this neoplasia. With the rising incidence and the underestimated prevalence of PNETs in the United States, it is paramount to discuss the challenges associated with the study and the management of this intractable disease for better patient outcomes. In this paper we elaborate on the comprehensive challenges and discuss novel and emerging therapeutic target in PNETs. |
| Publish Date |
2020-07-28 14:46 |
| Citation |
Mpilla GB, Philip PA, El-Rayes B, Azmi AS. Pancreatic neuroendocrine tumors: Therapeutic challenges and research limitations. World J Gastroenterol 2020; 26(28): 4036-4054 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i28/4036.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i28.4036 |
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