Publication Name	World Journal of Stem Cells
Manuscript ID	5627
Country	Germany

Received	2013-09-19 09:15
Peer-Review Started	2013-09-19 18:27
To Make the First Decision	2013-10-21 11:12
Return for Revision	2013-10-28 15:34
Revised	2013-11-24 23:46
Second Decision	2014-01-14 18:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-14 20:00
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-02-07 19:19
Typeset the Manuscript	2014-04-18 15:19
Publish the Manuscript Online	2014-04-28 14:14

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Developmental Biology
Manuscript Type	Autobiography
Article Title	Embryonic stem cell-derived neural progenitors as non-tumorigenic source for dopaminergic neurons
Manuscript Source	Invited Manuscript
All Author List	Mei-Chih Liao, Mihaela Diaconu, Sebastian Monecke, Patrick Collombat, Charles Timaeus, Tanja Kuhlmann, Walter Paulus, Claudia Trenkwalder, Ralf Dressel and Ahmed Mansouri
Funding Agency and Grant Number	Funding Agency Grant Number German Federal Ministry for Education and Research (BMBF) 01GN0818 German Federal Ministry for Education and Research (BMBF) 01GN0819 Max-Planck Society
Corresponding Author	Ahmed Mansouri, PhD, Professor, Department of Molecular Cell Biology, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany. amansou@gwdg.de
Key Words	Human embryonic stem cells; Neural progenitor cells; Teratoma; Pluripotency; Dopaminergic neurons
Core Tip	The use of pluripotent cells as a source for the generation of neuronal tissue for transplantation suffers from the risk of teratoma formation. To circumvent this problem, we have developed a simple and fast protocol to obtain human neural progenitor (HNP) cell lines from embryonic stem cells. These HNP cell lines have the potential to differentiate in vitro into dopaminergic neurons. After injection into immunodeficient SCID/beige mice, they did not form tumors even after 6 mo. These findings indicate that HNP cell lines can differentiate into dopaminergic neurons and bear no risk of generating teratomas in immunodeficient mice.
Publish Date	2014-04-28 14:14
Citation	Liao MC, Diaconu M, Monecke S, Collombat P, Timaeus C, Kuhlmann T, Paulus W, Trenkwalder C, Dressel R, Mansouri A. Embryonic stem cell-derived neural progenitors as non-tumorigenic source for dopaminergic neurons. World J Stem Cells 2014; 6(2): 248-255
URL	http://www.wjgnet.com/1948-0210/full/v6/i2/248.htm
DOI	http://dx.doi.org/10.4252/wjsc.v6.i2.248

Full Article (PDF)	WJSC-6-248.pdf
Full Article (Word)	WJSC-6-248.doc
Manuscript File	5627-Review.doc
Answering Reviewers	5627-Answering-reviewers.pdf
Copyright License Agreement	5627-Copyright assignment.pdf
Peer-review Report	5627-Peer reviewer(s).pdf
Scientific Editor Work List	5627-Scientific editor work list.doc