Publication Name	World Journal of Gastroenterology
Manuscript ID	5628
Country	Italy

Received	2013-09-18 10:06
Peer-Review Started	2013-09-18 17:46
To Make the First Decision	2013-10-29 12:44
Return for Revision	2013-11-01 17:24
Revised	2013-11-04 21:56
Second Decision	2013-12-03 21:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-12-04 06:35
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-06 14:07
Publish the Manuscript Online	2013-12-18 10:00

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Evidence-based appraisal of the upfront treatment for unresectable metastatic colorectal cancer patients
Manuscript Source	Invited Manuscript
All Author List	Giuseppe Aprile, Stefania Eufemia Lutrino, Laura Ferrari, Mariaelena Casagrande, Marta Bonotto, Elena Ongaro and Fabio Puglisi
Funding Agency and Grant Number
Corresponding Author	Giuseppe Aprile, MD, Department of Oncology, University and General Hospital, Piazzale S Maria della Misericordia 1, 33100 Udine, Italy. aprile.giuseppe@aoud.sanita.fvg.it
Key Words	Colorectal cancer; Chemotherapy; Angiogenic inhibitors; Epidermal growth factor receptor inhibitors; Maintenance; First-line
Core Tip	The choice of the first-line therapy is crucial for patients with advanced, unresectable colorectal cancer. The aim of this review is to critically focus on updated scientific data that medical oncologists need to interpret to make the most appropriate evidence-based choice among many possible treatment options.
Publish Date	2013-12-18 10:00
Citation	Aprile G, Lutrino SE, Ferrari L, Casagrande M, Bonotto M, Ongaro E, Puglisi F. Evidence-based appraisal of the upfront treatment for unresectable metastatic colorectal cancer patients. World J Gastroenterol 2013; 19(46): 8474-8488
URL	http://www.wjgnet.com/1007-9327/full/v19/i46/8474.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i46.8474

Full Article (PDF)	WJG-19-8474.pdf
Manuscript File	5628-Review.doc
Answering Reviewers	5628-Answering reviewers.pdf
Copyright License Agreement	5628-Copyright assignment.pdf
Peer-review Report	5628-Peer reviewer(s).pdf
Scientific Editor Work List	5628-Scientific editor work list.doc