| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Retrospective Study |
| Article Title |
High serum lactate dehydrogenase and dyspnea: Positive predictors for adverse event with critical COVID-19 patients in Yichang
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiao-Ting Lv, Yong-Ping Zhu, Ai-Guo Cheng, Yong-Xu Jin, Hai-Bo Ding, Cai-Yun Wang, Shu-Yu Zhang, Gong-Ping Chen, Qing-Quan Chen and Qi-Cai Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81800070 |
| Development Fund Program of Fujian Provincial Health and Family Planning Commission |
2017-1-43 |
|
| Corresponding Author |
Qi-Cai Liu, MD, Chief Technician, Doctor, Teacher, Department of Reproductive Medicine Centre, First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou 350005, Fujian Province, China. lqc673673673@163.com |
| Key Words |
COVID-19; SARS-CoV-2; Lactate dehydrogenase; Pulmonary fibrosis; Dyspnea; Overall survival |
| Core Tip |
We explored the serum lactate dehydrogenase (LDH) and clinical characteristics in critical coronavirus disease 2019 (COVID-19) patients and its predictive value for prognosis. We retrospective evaluated 47 critical COVID-19 patients and divided them into non-survivors and survivors groups. Clinical data including symptoms, detection of severe acute respiratory syndrome coronavirus 2, chest computed tomography images, changes of serum LDH in different clinical phases, and prognosis was collected. In our study, high LDH was obviously positively correlated with worsening overall survival. High LDH and dyspnea symptom were positive predictors for adverse event in critical COVID-19 patients. The rapid progressive fibrosis stage may be more perilous than alveolitis stage, even if severe acute respiratory syndrome coronavirus 2 was undetectable. |
| Publish Date |
2020-11-25 14:44 |
| Citation |
Lv XT, Zhu YP, Cheng AG, Jin YX, Ding HB, Wang CY, Zhang SY, Chen GP, Chen QQ, Liu QC. High serum lactate dehydrogenase and dyspnea: Positive predictors for adverse event with critical COVID-19 patients in Yichang. World J Clin Cases 2020; 8(22): 5535-5546 |
| URL |
https://www.wjgnet.com/2307-8960/full/v8/i22/5535.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v8.i22.5535 |
