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Articles Published Processes
9/9/2020 11:11:52 AM | Browse: 1190 | Download: 3410
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Received |
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2020-04-24 07:14 |
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Peer-Review Started |
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2020-04-24 07:15 |
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First Decision by Editorial Office Director |
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2020-05-15 22:51 |
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Return for Revision |
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2020-05-15 22:51 |
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Revised |
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2020-05-19 09:20 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-08-19 10:52 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-08-19 18:33 |
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Articles in Press |
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2020-08-19 18:33 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-09-09 01:06 |
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Publish the Manuscript Online |
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2020-09-09 11:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
A biomarker for assessing cirrhosis and prognosis of liver disease patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Nikolaos K Gatselis, Tamás Tornai, Zakera Shums, Kalliopi Zachou, Asterios Saitis, Stella Gabeta, Roger Albesa, Gary L Norman, Mária Papp and George N Dalekos |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
George N Dalekos, MD, PhD, Full Professor, Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Mezourlo, Larissa 41110, Greece. georgedalekos@gmail.com;dalekos@med.uth.gr |
| Key Words |
Biomarker; Golgi protein-73; Hepatic fibrosis; Cirrhosis; Hepatocellular carcinoma; Hepatitis B; Hepatitis C; Aspartate aminotransferase/Platelets ratio index score |
| Core Tip |
This retrospective study evaluated the utility of serum Golgi protein-73 (GP73) determination as a diagnostic marker of cirrhosis and/or hepatocellular carcinoma (HCC) or as a predictor of liver disease progression in a large cohort of 632 consecutive patients suffering from diverse liver diseases diagnosed and followed in two tertiary care hospitals in Greece and Hungary. We found that GP73 was quite efficient for detecting cirrhosis and superior to Aspartate aminotransferase (AST)/Platelets (PLT) ratio index (APRI) determination. In combination with APRI score, its diagnostic performance can be further improved. Most importantly, however, the simple GP73 measurement proved promising for predicting a worse outcome during follow-up in patients with both viral and non-viral chronic liver diseases. |
| Publish Date |
2020-09-09 11:11 |
| Citation |
Gatselis NK, Tornai T, Shums Z, Zachou K, Saitis A, Gabeta S, Albesa R, Norman GL, Papp M, Dalekos GN. Golgi protein-73: A biomarker for assessing cirrhosis and prognosis of liver disease patients. World J Gastroenterol 2020; 26(34): 5130-5145
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| URL |
https://www.wjgnet.com/1007-9327/full/v26/i34/5130.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i34.5130 |
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