Publication Name	World Journal of Gastroenterology
Manuscript ID	5630
Country	Belgium

Received	2013-09-18 10:26
Peer-Review Started	2013-09-18 17:11
To Make the First Decision	2013-10-29 12:44
Return for Revision	2013-11-01 17:57
Revised	2013-11-18 18:27
Second Decision	2014-01-06 17:30
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-06 19:07
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-20 09:55
Publish the Manuscript Online	2014-01-26 20:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Neuroanatomy of lower gastrointestinal pain disorders
Manuscript Source	Invited Manuscript
All Author List	Wim Vermeulen, Joris G De Man, Paul A Pelckmans and Benedicte Y De Winter
Funding Agency and Grant Number
Corresponding Author	Benedicte Y De Winter, MD, PhD, Executive Director, Laboratory of Experimental Medicine and Pediatrics, Division of Gastroenterology, Faculty of Medicine and Health Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. benedicte.dewinter@uantwerpen.be
Key Words	Afferent nerves; Chronic pain; Inflammatory bowel disease; Irritable bowel syndrome; Sensitisation; Sensory nerves; Visceral hypersensitivity
Core Tip	This review reports on the neuroanatomy of gastrointestinal pain disorders. The encoding and conveying of information from the gastrointestinal wall to the central nervous system is described with emphasis on the peripheral level, the spinal cord and the higher brain centers. Besides the basic principles of visceral hypersensitivity are reviewed taking into consideration peripheral sensitization (and the main mediators involved) and central wind-up phenomena in order to better understand the mechanisms involved in chronic abdominal pain in inflammatory bowel disease and irritable bowel syndrome patients.
Publish Date	2014-01-26 20:08
Citation	Vermeulen W, De Man JG, Pelckmans PA, De Winter BY. Neuroanatomy of lower gastrointestinal pain disorders. World J Gastroenterol 2014; 20(4): 1005-1020
URL	http://www.wjgnet.com/1007-9327/full/v20/i4/1005.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i4.1005

Full Article (PDF)	WJG-20-1005.pdf
Full Article (Word)	WJG-20-1005.doc
Manuscript File	5630-Review.doc
Answering Reviewers	5630-Answering reviewers.pdf
Copyright License Agreement	5630-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5630-Language certificate.PDF
Peer-review Report	5630-Peer reviewer(s).pdf
Scientific Editor Work List	5630-Scientific editor work list.doc