Publication Name	World Journal of Gastroenterology
Manuscript ID	5631
Country	Spain

Received	2013-09-18 10:42
Peer-Review Started	2013-09-18 16:56
To Make the First Decision	2013-12-16 18:15
Return for Revision	2013-12-18 09:50
Revised	2014-01-01 00:29
Second Decision	2014-02-20 09:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-20 09:37
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-04-11 10:16
Publish the Manuscript Online	2014-04-17 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Role of cetuximab in first-line treatment of metastatic colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Miguel Jhonatan Sotelo, Beatriz García-Paredes, Carlos Aguado, Javier Sastre and Eduardo Díaz-Rubio
Funding Agency and Grant Number
Corresponding Author	Eduardo Díaz-Rubio, MD, PhD, Department of Medicine, School of Medicine, Universidad Complutense de Madrid, Oncology Department, Hospital Clínico San Carlos. Prof. Martín Lagos, s/n, 28040 Madrid, Spain. ediazrubio.hcsc@salud.madrid.org
Key Words	Cetuximab; First-line; Metastatic colorectal cancer; Colorectal liver metastases; Elderly patients
Core Tip	This article contains updated data regarding biomarkers of response to epidermal growth factor receptor-targeted therapy and reviews the major studies that have evaluated the efficacy of cetuximab in the first-line treatment of metastatic colorectal cancer (mCRC). We have also compiled the most important data supporting the use of cetuximab in the neoadjuvant treatment of colorectal liver metastases. Finally, we review the current evidence regarding the efficacy and safety of cetuximab in the treatment of elderly patients with mCRC.
Publish Date	2014-04-17 13:27
Citation	Sotelo MJ, García-Paredes B, Aguado C, Sastre J, Díaz-Rubio E. Role of cetuximab in first-line treatment of metastatic colorectal cancer. World J Gastroenterol 2014; 20(15): 4208-4219
URL	http://www.wjgnet.com/1007-9327/full/v20/i15/4208.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i15.4208

Full Article (PDF)	WJG-20-4208.pdf
Full Article (Word)	WJG-20-4208.doc
Manuscript File	5631-Review.docx
Answering Reviewers	5631-Answering reviewers.pdf
Copyright License Agreement	5631-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5631-Language certificate.pdf
Peer-review Report	5631-Peer reviewer(s).pdf
Scientific Editor Work List	5631-Scientific editor work list.doc