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10/26/2020 12:01:03 PM | Browse: 388 | Download: 687
Publication Name World Journal of Stem Cells
Manuscript ID 56404
Country/Territory United States
2020-04-29 14:39
Peer-Review Started
2020-04-29 14:39
To Make the First Decision
Return for Revision
2020-05-24 21:51
2020-06-02 02:21
Second Decision
2020-09-22 10:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-09-22 20:19
Articles in Press
2020-09-22 20:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-10-16 02:37
Publish the Manuscript Online
2020-10-26 12:01
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Inflammatory bowel disease: Therapeutic limitations and prospective of the stem cell therapy
Manuscript Source Invited Manuscript
All Author List Rangnath Mishra, Punita Dhawan, Anand S Srivastava and Amar B Singh
Author(s) ORCID Number
Rangnath Mishra http://orcid.org/0000-0001-7118-7114
Punita Dhawan http://orcid.org/0000-0003-3434-8155
Anand S Srivastava http://orcid.org/0000-0002-5805-9801
Amar B Singh http://orcid.org/0000-0003-1908-8594
Funding Agency and Grant Number
Funding Agency Grant Number
Department of Veterans Affairs 2I01BX002761-05
Department of Veterans Affairs 2I01BX002086-06A1
The National Institutes of Health 1R01DK124095-01A1
The National Institutes of Health 1R21CA216746-01A1
Corresponding Author Amar B Singh, PhD, Professor, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, NA, Omaha, NE 68118, United States. amar.singh@unmc.edu
Key Words Crohn′s disease; Ulcerative colitis; Mesenchymal stem cells; Hematopoietic stem cells; Mucosal healing;
Core Tip Mucosal healing is gaining acceptance as a measure of the disease activity remission in inflammatory bowel disease (IBD) patients, however, its regulation and means of therapeutic targeting remain unclear. In this article, we elaborate upon stem-cell therapy, which uses hematopoietic or mesenchymal stem cells, as a promising therapeutic option for IBD. The over-reaching concept is that the stem cells can migrate to the damaged areas of the intestine and differentiate into the mature intestinal epithelial cells to restore the barrier integrity of the intestinal lining, and hence, prevent the immunomodulatory induction, the root cause of IBD, and thus patient’s quality of life.
Publish Date 2020-10-26 12:01
Citation Mishra R, Dhawan P, Srivastava AS, Singh AB. Inflammatory bowel disease: Therapeutic limitations and prospective of the stem cell therapy. World J Stem Cells 2020; 12(10): 1050-1066
URL https://www.wjgnet.com/1948-0210/full/v12/i10/1050.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i10.1050
Full Article (PDF) WJSC-12-1050.pdf
Full Article (Word) WJSC-12-1050.docx
Manuscript File 56404-Review.docx
Answering Reviewers 56404-Answering reviewers.pdf
Audio Core Tip 56404-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 56404-Conflict-of-interest statement.pdf
Copyright License Agreement 56404-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 56404-Grant application form(s).pdf
Peer-review Report 56404-Peer-review(s).pdf
Scientific Misconduct Check 56404-Scientific misconduct check.pdf
Scientific Editor Work List 56404-Scientific editor work list.pdf