Publication Name	World Journal of Gastroenterology
Manuscript ID	5641
Country	Denmark

Received	2013-09-19 08:34
Peer-Review Started	2013-09-19 17:46
To Make the First Decision	2013-10-14 21:27
Return for Revision	2013-10-20 20:48
Revised	2013-10-23 19:24
Second Decision	2013-12-03 21:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-12-04 06:38
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-27 16:37
Publish the Manuscript Online	2014-01-20 17:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Inflammatory pathways of importance for management of inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Jannie Pedersen, Mehmet Coskun, Christoffer Soendergaard, Mohammad Salem and Ole Haagen Nielsen
Funding Agency and Grant Number	Funding Agency Grant Number Foundation of Aase and Ejnar Danielsen Foundation of Axel Muusfeldt A P Møller Foundation (“Fonden til Lægevidenskabens Fremme”)
Corresponding Author	Mehmet Coskun, PhD, Department of Gastroenterology, Medical Section, University of Copenhagen, Herlev Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark. mehmet.coskun@regionh.dk
Key Words	Anti-tumor necrosis factor; Biologics; Crohn’s disease; Pro-inflammatory cytokines; Signaling pathways; Treatment; Ulcerative colitis
Core Tip	Crohn’s disease and ulcerative colitis are the two prevailing forms of inflammatory bowel disease (IBD). Both diseases are associated with an increased expression of pro-inflammatory cytokines and immune cell infiltration of the inflamed tissue. Current treatment options with tumor necrosis factor-α inhibitors are discussed. Additionally, new therapeutic strategies showing promising results, e.g., small pharmacologic inhibitors aimed at inhibiting Janus kinase pathway and antibodies blocking recruitment of immune cells to the site of inflammation are also discussed. In this review we have elucidated the major signaling pathways of clinical importance for new therapeutic strategies of IBD.
Publish Date	2014-01-20 17:10
Citation	Pedersen J, Coskun M, Soendergaard C, Salem M, Nielsen OH. Inflammatory pathways of importance for management of inflammatory bowel disease. World J Gastroenterol 2014; 20(1): 64-77
URL	http://www.wjgnet.com/1007-9327/full/v20/i1/64.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i1.64

Full Article (PDF)	WJG-20-6.pdf
Full Article (Word)	WJG-20-6.doc
Manuscript File	5641-Review.doc
Answering Reviewers	5641-Answering reviewers.pdf
Copyright License Agreement	5641-Copyright assignment.PDF
Peer-review Report	5641-Peer reviewer(s).pdf
Scientific Editor Work List	5641-Scientific editor work list.doc