Publication Name	World Journal of Gastroenterology
Manuscript ID	5651
Country	China

Received	2013-09-20 10:20
Peer-Review Started	2013-09-21 19:53
First Decision by Editorial Office Director
Return for Revision	2013-12-16 14:27
Revised	2013-12-31 13:14
Publication Fee Transferred
Second Decision by Editor	2014-01-20 17:15
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-01-20 18:17
Articles in Press
Edit the Manuscript by Language Editor	2014-02-21 22:00
Typeset the Manuscript	2014-03-03 12:25
Publish the Manuscript Online	2014-03-06 14:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Autobiography
Article Title	Prognostic value of M30/M65 for outcome of hepatitis B virus-related acute-on-chronic liver failure
Manuscript Source	Invited Manuscript
All Author List	Su-Jun Zheng, Shuang Liu, Mei Liu, Malcolm A McCrae, Jun-Feng Li, Yuan-Ping Han, Chun-Hui Xu, Feng Ren, Yu Chen and Zhong-Ping Duan
Funding Agency and Grant Number	Funding Agency Grant Number National Science and Technology Key Project of China 2012ZX10002004-006 National Science and Technology Key Project of China 2012ZX10004904-003-001 National Science and Technology Key Project of China 2013ZX10002002-006-001 Beijing Municipal Science and Technology Commission Z131107002213019 Beijing Municipal Science and Technology Commission Z131100004613030 High Technical Personnel Training Program in Beijing Health System 2011-3-083 High Technical Personnel Training Program in Beijing Health System 2013-3-071 Special Scientific Research Fund for Beijing Health Development 2011-2018-04 National Natural Science Foundation of China 30800979 National Natural Science Foundation of China 30800517
Corresponding Author	Yu Chen, PhD, MD, Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, No. 8, Xitou Tiao Road, Youwai Street, Beijing 100069, China. chybeyond@163.com
Key Words	Acute-on-chronic liver failure; Chronic hepatitis B virus infection; Liver disease stage; Liver disease severity; Serum M65 level; Serum M30 level; Prognostic value
Core Tip	Massive hepatic cell death is a key characteristic of liver failure. Enzyme-linked immunosorbent assay was used to measure M65 and M30 in a chronic hepatitis B (CHB) infection cohort which included healthy controls, CHB and acute-on-chronic liver failure (ACLF) patients. Elevated M65 and M30 differentiated CHB or ACLF patients from healthy controls and gradually increased with disease severity. M30/M65 was significantly increased in ACLF patients with spontaneous recovery (P = 0.032), and the AUC of this ratio at the 3-mo survival period was 0.661 (sensitivity: 52.9%) with a high specificity (92.6%) compared with the Model for End-Stage Liver Disease and Child-Pugh scores.
Publish Date	2014-03-06 14:13
Citation	Zheng SJ, Liu S, Liu M, McCrae MA, Li JF, Han YP, Xu CH, Ren F, Chen Y, Duan ZP. Prognostic value of M30/M65 for outcome of hepatitis B virus-related acute-on-chronic liver failure. World J Gastroenterol 2014; 20(9): 2403-2411
URL	http://www.wjgnet.com/1007-9327/full/v20/i9/2403.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i9.2403

Full Article (PDF)	WJG-20-2403.pdf
Full Article (Word)	WJG-20-2403.doc
Manuscript File	5651-Review.doc
Answering Reviewers	5651-Answering reviewers.pdf
Biostatistics Review Certificate	Biostatistician_Review_Report_20130919103644.pdf
Copyright License Agreement	5651-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20130919103623.pdf
Non-Native Speakers of English Editing Certificate	5651-Language certificate.doc
Peer-review Report	5651-Peer reviewer(s).pdf
Scientific Editor Work List	5651-Scientific editor work list.doc