Publication Name	World Journal of Gastroenterology
Manuscript ID	56536
Country	United States

Received	2020-05-05 21:58
Peer-Review Started	2020-05-05 21:59
To Make the First Decision
Return for Revision	2020-05-15 18:13
Revised	2020-05-21 09:16
Second Decision	2020-08-26 09:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-08-27 00:39
Articles in Press	2020-08-27 00:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-09-03 06:13
Publish the Manuscript Online	2020-09-04 07:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Frontier
Article Title	Treatment repurposing for inflammatory bowel disease using literature-related discovery and innovation
Manuscript Source	Invited Manuscript
All Author List	Ronald Neil Kostoff, Michael Brandon Briggs and Darla Roye Shores
ORCID	Author(s) ORCID Number Ronald Neil Kostoff http://orcid.org/0000-0002-4434-2147 Michael Brandon Briggs http://orcid.org/0000-0003-0163-2918 Darla Roye Shores http://orcid.org/0000-0002-0551-7880
Funding Agency and Grant Number
Corresponding Author	Ronald Neil Kostoff, PhD, Research Fellow, School of Public Policy, Georgia Institute of Technology, 13500 Tallyrand Way, Gainesville, VA 20155, United States. ronald.kostoff@pubpolicy.gatech.edu
Key Words	Treatment repurposing; Treatment repositioning; Inflammatory bowel disease; Literature-based discovery; Text mining; Crohn’s disease
Core Tip	A text-mining approach was used to identify treatments from non-inflammatory bowel disease (IBD) diseases that could be extrapolated to treat IBD. Sixty-four treatment concepts were identified in different phases of development, ranging from laboratory research to clinical application. Many more were possible with a longer and well-resourced study. Ten of the non-IBD concepts that were excluded from being classified as discovery would have been classified as discovery if the study had been conducted in 2016. Thus, this approach has the capability to identify/predict many new areas of research for treating IBD.
Publish Date	2020-09-04 07:25
Citation	Kostoff RN, Briggs MB, Shores DR. Treatment repurposing for inflammatory bowel disease using literature-related discovery and innovation. World J Gastroenterol 2020; 26(33): 4889-4899
URL	https://www.wjgnet.com/1007-9327/full/v26/i33/4889.htm
DOI	https://dx.doi.org/10.3748/wjg.v26.i33.4889

Full Article (PDF)	WJG-26-4889.pdf
Full Article (Word)	WJG-26-4889.docx
Manuscript File	56536-Review.docx
Answering Reviewers	56536-Answering reviewers.pdf
Audio Core Tip	56536-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	56536-Conflict-of-interest statement.pdf
Copyright License Agreement	56536-Copyright license agreement.pdf
Supplementary Material	56536-Supplementary material.pdf
Peer-review Report	56536-Peer-review(s).pdf
Scientific Misconduct Check	56536-Scientific misconduct check.pdf
Scientific Editor Work List	56536-Scientific editor work list.pdf
CrossCheck Report	56536-CrossCheck Report.pdf