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9/2/2014 5:02:00 PM | Browse: 684 | Download: 368
Publication Name World Journal of Gastroenterology
Manuscript ID 5663
Country/Territory Greece
2013-09-20 11:09
Peer-Review Started
2013-09-21 20:00
To Make the First Decision
2013-10-14 21:26
Return for Revision
2013-10-20 18:45
2013-10-29 19:37
Second Decision
2014-01-06 18:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-01-06 19:04
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-02-11 11:21
Publish the Manuscript Online
2014-03-12 11:24
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Meta-Analysis
Article Title Statins and the risk of colorectal cancer: An updated systematic review and meta-analysis of 40 studies
Manuscript Source Invited Manuscript
All Author List Theodore Lytras, Georgios Nikolopoulos and Stefanos Bonovas
Funding Agency and Grant Number
Corresponding author Theodore Lytras, MD, MPH, Department of Occupational and Industrial Hygiene, National School of Public Health, 196 Alexandras Ave., 11521 Athens, Greece. thlytras@gmail.com
Key Words 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors; Statins; Colorectal cancer; Systematic review; Meta-analysis; Cancer chemoprevention
Core Tip To investigate the association between statin use and colorectal cancer risk, we conducted a systematic review and meta-analysis of published studies. A total of 40 studies, involving more than eight million subjects, contributed to our analysis. A modest reduction in the risk of colorectal cancer with statin use was observed, which was not statistically significant among RCTs (RR = 0.89, 95%CI: 0.74-1.07; n = 8), but reached statistical significance among cohort studies (RR = 0.91, 95%CI: 0.83-1.00; n = 13) and case-control studies (RR = 0.92, 95%CI: 0.87-0.98; n = 19). Further targeted research is warranted.
Publish Date 2014-03-12 11:24
Citation Lytras T, Nikolopoulos G, Bonovas S. Statins and the risk of colorectal cancer: An updated systematic review and meta-analysis of 40 studies. World J Gastroenterol 2014; 20(7): 1858-1870
Url http://www.wjgnet.com/1007-9327/full/v20/i7/1858.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i7.1858
Full Article (PDF) WJG-20-1858.pdf
Full Article (Word) WJG-20-1858.doc
Manuscript File 5663-Review.doc
Answering Reviewers 5663-Answering reviewers.pdf
Copyright License Agreement 5663-Copyright assignment.pdf
Peer-review Report 5663-Peer reviewer(s).pdf
Scientific Editor Work List 5663-Scientific editor work list.doc