| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Hepatitis B surface antigen and hepatitis B core-related antigen kinetics after adding pegylated-interferon to nucleoside analogues in hepatitis B e antigen-negative patients
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Teresa Broquetas, Montserrat Garcia-Retortillo, Miquel Micó, Lidia Canillas, Marc Puigvehí, Nuria Cañete, Susana Coll, Ana Viu, Juan Jose Hernandez, Xavier Bessa and José A Carrión |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Instituto de Salud Carlos III, Ministerio de Economía y Competitividad |
PI14/00540 |
|
| Corresponding Author |
José A Carrión, MD, PhD, Doctor, Department of Gastroenterology, Liver Section, Hospital del Mar Medical Research Institute, Parc de Salut Mar, Passeig Marítim 25-29, Barcelona 08003, Spain. 95565@parcdesalutmar.cat |
| Key Words |
Chronic hepatitis B; Hepatitis B e antigen-negative; Hepatitis B surface antigen; Hepatitis B core-related antigen; Pegylated-interferon; Nucleos(t)ids analogues |
| Core Tip |
The functional cure of chronic hepatitis B defined as the loss of the hepatitis B surface antigen is the optimal end-point with the currently available therapies. However, it is rarely achieved in hepatitis B e antigen-negative chronic hepatitis B patients under nucleos(t)ids analogues (NAs). In the present study, we report that the addition of Peg-IFN to NAs during forty-eight weeks caused a greater and faster decrease of hepatitis B surface antigen levels compared to NA monotherapy. No changes in hepatitis B core-related antigen were observed. However, the low applicability and poor tolerance of Peg-IFN make difficult its use in clinical practice. |
| Publish Date |
2020-11-24 12:41 |
| Citation |
Broquetas T, Garcia-Retortillo M, Micó M, Canillas L, Puigvehí M, Cañete N, Coll S, Viu A, Hernandez JJ, Bessa X, Carrión JA. Hepatitis B surface antigen and hepatitis B core-related antigen kinetics after adding pegylated-interferon to nucleos(t)ids analogues in hepatitis B e antigen-negative patients. World J Hepatol 2020; 12(11): 1076-1088 |
| URL |
https://www.wjgnet.com/1948-5182/full/v12/i11/1076.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v12.i11.1076 |
