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Articles Published Processes
11/23/2020 10:54:17 AM | Browse: 724 | Download: 1633
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Received |
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2020-05-15 13:43 |
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Peer-Review Started |
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2020-05-15 13:44 |
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To Make the First Decision |
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Return for Revision |
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2020-05-24 21:00 |
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Revised |
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2020-06-18 13:37 |
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Second Decision |
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2020-09-17 12:52 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-09-18 20:31 |
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Articles in Press |
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2020-09-18 20:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-10-10 06:31 |
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Typeset the Manuscript |
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2020-11-08 05:45 |
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Publish the Manuscript Online |
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2020-11-23 10:54 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Exploring the safety and efficacy of adding ketoconazole to tacrolimus in pediatric renal transplant immunosuppression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sindy Méndez, Brooke M Ramay, Angie Aguilar-González and Randall Lou-Meda |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Brooke M Ramay, BSc, PharmD, Pharmacist, Professor, Department of Pharmaceutical Chemistry, Universidad del Valle de Guatemala, 18 Avenida 11-95, Guatemala 01015, Guatemala. bramay@uvg.edu.gt |
| Key Words |
Transplant; Immunosuppression; Tacrolimus; Ketoconazole; Pediatric; Chart review |
| Core Tip |
In the most advanced stages of chronic kidney disease transplantation improves patient survival. But in low to middle income countries transplantation is not feasible due to high cost associated to transplant maintenance. Expenditures may be mitigated by pharmacokinetically boosting transplant medications. We present the addition of ketoconazole to post transplant regimens to boost therapeutic levels of tacrolimus, thus maintaining efficacy while reducing total daily doses. We found that therapeutic levels of tacrolimus were preserved during the study period, patients demonstrated an improvement in estimated glomerular filtration rate and a 21% reduction in medication cost. |
| Publish Date |
2020-11-23 10:54 |
| Citation |
Méndez S, Ramay BM, Aguilar-González A, Lou-Meda R. Exploring the safety and efficacy of adding ketoconazole to tacrolimus in pediatric renal transplant immunosuppression. World J Transplant 2020; 10(11): 356-364 |
| URL |
https://www.wjgnet.com/2220-3230/full/v10/i11/356.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v10.i11.356 |
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