Publication Name	World Journal of Gastroenterology
Manuscript ID	5678
Country	Italy

Received	2013-09-22 11:38
Peer-Review Started	2013-09-24 10:20
To Make the First Decision	2013-10-29 12:44
Return for Revision	2013-11-01 17:29
Revised	2013-11-13 18:20
Second Decision	2014-01-06 18:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-06 19:03
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-24 14:55
Publish the Manuscript Online	2014-03-27 12:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma: An intricate pathway
Manuscript Source	Invited Manuscript
All Author List	Romilda Cardin, Marika Piciocchi, Marina Bortolami, Andromachi Kotsafti, Luisa Barzon, Enrico Lavezzo, Alessandro Sinigaglia, Kryssia Isabel Rodriguez-Castro, Massimo Rugge and Fabio Farinati
Funding Agency and Grant Number
Corresponding Author	Fabio Farinati, MD, Professor, Department of Surgery, Oncology and Gastroenterology, University of Padova, Via Giustiniani 2, 35128 Padova, Italy. fabio.farinati@unipd.it
Key Words	Reactive oxygen species; Viral hepatitis; Hepatocellular carcinoma; Telomere dysfunction; Cytokines; mitochondria; Antioxidant mechanisms; MicroRNA and circulating free DNA
Core Tip	In this review, the relationship amongst chronic liver injury, free radical production, and development of hepatocellular carcinoma is explored. The review confirms the existence, in the intricate pathway involved in the progression of virus-related liver injury to cirrhosis and cancer, of a link between oxidative genomic and mitochondrial damage and telomere dysfunction. This link develops in the context of inflammatory response and induces a derangement of mechanisms controlling liver proliferation. In this scenario, mitochondria are emerging as a possible target for new treatments aimed at counteracting oxidative damage and disease progression to cancer, given their relevant role in inflammation and carcinogenesis.
Publish Date	2014-03-27 12:04
Citation	Cardin R, Piciocchi M, Bortolami M, Kotsafti A, Barzon L, Lavezzo E, Sinigaglia A, Rodriguez-Castro KI, Rugge M, Farinati F. Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma: An intricate pathway. World J Gastroenterol 2014; 20(12): 3078-3086
URL	http://www.wjgnet.com/1007-9327/full/v20/i12/3078.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i12.3078

Full Article (PDF)	WJG-20-3078.pdf
Full Article (Word)	WJG-20-3078.doc
Manuscript File	5678-Review.docx
Answering Reviewers	5678-Answering reviewers.pdf
Copyright License Agreement	5678-Copyright assignment.pdf
Peer-review Report	5678-Peer reviewer(s).pdf
Scientific Editor Work List	5678-Scientific editor work list.doc