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9/1/2014 11:02:00 AM | Browse: 1080 | Download: 756
Publication Name World Journal of Gastroenterology
Manuscript ID 5678
Country/Territory Italy
Received
2013-09-22 11:38
Peer-Review Started
2013-09-24 10:20
To Make the First Decision
2013-10-29 12:44
Return for Revision
2013-11-01 17:29
Revised
2013-11-13 18:20
Second Decision
2014-01-06 18:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-01-06 19:03
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-02-24 14:55
Publish the Manuscript Online
2014-03-27 12:04
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Topic Highlights
Article Title Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma: An intricate pathway
Manuscript Source Invited Manuscript
All Author List Romilda Cardin, Marika Piciocchi, Marina Bortolami, Andromachi Kotsafti, Luisa Barzon, Enrico Lavezzo, Alessandro Sinigaglia, Kryssia Isabel Rodriguez-Castro, Massimo Rugge and Fabio Farinati
Funding Agency and Grant Number
Corresponding Author Fabio Farinati, MD, Professor, Department of Surgery, Oncology and Gastroenterology, University of Padova, Via Giustiniani 2, 35128 Padova, Italy. fabio.farinati@unipd.it
Key Words Reactive oxygen species; Viral hepatitis; Hepatocellular carcinoma; Telomere dysfunction; Cytokines; mitochondria; Antioxidant mechanisms; MicroRNA and circulating free DNA
Core Tip In this review, the relationship amongst chronic liver injury, free radical production, and development of hepatocellular carcinoma is explored. The review confirms the existence, in the intricate pathway involved in the progression of virus-related liver injury to cirrhosis and cancer, of a link between oxidative genomic and mitochondrial damage and telomere dysfunction. This link develops in the context of inflammatory response and induces a derangement of mechanisms controlling liver proliferation. In this scenario, mitochondria are emerging as a possible target for new treatments aimed at counteracting oxidative damage and disease progression to cancer, given their relevant role in inflammation and carcinogenesis.
Publish Date 2014-03-27 12:04
Citation Cardin R, Piciocchi M, Bortolami M, Kotsafti A, Barzon L, Lavezzo E, Sinigaglia A, Rodriguez-Castro KI, Rugge M, Farinati F. Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma: An intricate pathway. World J Gastroenterol 2014; 20(12): 3078-3086
URL http://www.wjgnet.com/1007-9327/full/v20/i12/3078.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i12.3078
Full Article (PDF) WJG-20-3078.pdf
Full Article (Word) WJG-20-3078.doc
Manuscript File 5678-Review.docx
Answering Reviewers 5678-Answering reviewers.pdf
Copyright License Agreement 5678-Copyright assignment.pdf
Peer-review Report 5678-Peer reviewer(s).pdf
Scientific Editor Work List 5678-Scientific editor work list.doc