| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Acupuncture improved lipid metabolism by regulating intestinal absorption in mice
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia Han, Xin Guo, Xiang-Jin Meng, Jing Zhang, Reimon Yamaguchi, Yoshiharu Motoo and Sohsuke Yamada |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grants-in-Aid for Scientific Research |
19K16783 |
| Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan |
20K07454,20K17363 |
| Grant for Promoted Research from Kanazawa Medical University |
S2018-6 |
|
| Corresponding Author |
Xin Guo, PhD, Doctor, Department of Pathology and Laboratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa 920-0293, Japan. tianqi11211216@yahoo.co.jp |
| Key Words |
Acupuncture; Non-alcoholic fatty liver disease; Small intestine; Lipid metabolism; Apolipoproteins; |
| Core Tip |
In the present study, our experimental data showed that acupuncture treatment suppressed high-fat-induced body weight gain, reduced the accumulation of intra-abdominal fat, inhibited lipid absorption in the small intestine and downregulated the blood lipid level in mice with non-alcoholic fatty liver disease, suggesting that acupuncture potentially had variable beneficial effects in improving the lipid metabolism in the presence of abnormal liver metabolism. Furthermore, we also found more fat deposition in the intestinal epithelium with the decreased expression of some intestinal apolipoproteins in acupuncture-treated mice, suggesting that acupuncture may suppress lipid absorption by downregulating the expression of apolipoproteins in the small intestine. |
| Publish Date |
2020-09-09 11:11 |
| Citation |
Han J, Guo X, Meng XJ, Zhang J, Yamaguchi R, Motoo Y, Yamada S. Acupuncture improved lipid metabolism by regulating intestinal absorption in mice. World J Gastroenterol 2020; 26(34): 5118-5129 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i34/5118.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i34.5118 |
