BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/19/2020 3:49:20 AM | Browse: 819 | Download: 1766
 |
Received |
|
2020-05-16 19:34 |
|
Peer-Review Started |
|
2020-05-16 19:35 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2020-06-06 12:05 |
|
Revised |
|
2020-06-06 15:39 |
|
Second Decision |
|
2020-08-25 08:13 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2020-08-26 04:45 |
|
Articles in Press |
|
2020-08-26 04:45 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
2020-08-28 18:06 |
|
Typeset the Manuscript |
|
2020-09-15 13:33 |
|
Publish the Manuscript Online |
|
2020-09-19 03:49 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Diacerein treatment prevents colitis-associated cancer in mice
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Daiane S M Paulino, Maria Carolina S Mendes, Juliana A Camargo, Sandra R Brambilla, Tanila Wood Dos Santos, Marcelo L Ribeiro and José Barreto Campello Carvalheira |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| São Paulo Research Foundation |
07607-8/2013 |
| National Research Council |
150127/2016-2 |
| National Research Council |
306821/2010-9 |
|
| Corresponding Author |
José Barreto Campello Carvalheira, MD, PhD, Associate Professor, Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Tessália Vieira Camargo, S/N, Sao Paulo 13083-970, Brazil. jbcc@unicamp.br |
| Key Words |
Colon cancer; Cancer stem cell; Chemoprevention; ; ; |
| Core Tip |
Inflammation is a well-established factor for colitis-associated cancer (CAC) development. In accordance, chronic inflammation has been implicated in cancer stem cells (CSCs) development. The present study evaluates the role of diacerein (DAR), an anti-inflammatory drug, in the development of an experimental model of CSCs and CAC. DAR treatment reduced colon inflammation, number and size of tumors. DAR treatment was associated with reduced intracellular signals of inflammation (inhibitor of nuclear factor kappa B kinase and c-Jun N-terminal kinase phosphorylation) in colon. DAR treatment was associated with a decrease in colon CSC formation, suggesting that besides reducing colonic inflammation, DAR has a direct effect on the inhibition of colon carcinogenesis. |
| Publish Date |
2020-09-19 03:49 |
| Citation |
Paulino DSM, Mendes MCS, Camargo JA, Brambilla SR, Wood Dos Santos T, Ribeiro ML, Carvalheira JBC. Diacerein treatment prevents colitis-associated cancer in mice. World J Clin Oncol 2020; 11(9): 732-746 |
| URL |
https://www.wjgnet.com/2218-4333/full/v11/i9/732.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v11.i9.732 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
