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Articles Published Processes
10/26/2020 9:59:39 AM | Browse: 419 | Download: 892
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Received |
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2020-05-17 12:39 |
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Peer-Review Started |
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2020-05-17 12:40 |
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To Make the First Decision |
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Return for Revision |
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2020-07-25 05:21 |
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Revised |
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2020-07-29 11:25 |
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Second Decision |
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2020-08-31 11:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-08-31 20:09 |
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Articles in Press |
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2020-08-31 20:09 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-09-08 15:01 |
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Typeset the Manuscript |
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2020-10-21 07:52 |
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Publish the Manuscript Online |
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2020-10-26 09:59 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Mycology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Remission of hepatotoxicity in chronic pulmonary aspergillosis patients after lowering trough concentration of voriconazole
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Guo-Jie Teng, Xiang-Rong Bai, Lin Zhang, Hong-Jun Liu and Xiu-Hong Nie |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xiu-Hong Nie, PhD, Chief Doctor, Department of Pulmonary and Critical Care Medicine, Xuanwu Hospital Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China. xiuhongnie@126.com |
| Key Words |
Voriconazole; Hepatotoxicity; Chronic pulmonary aspergillosis; CYP2C19 genotypes; Reduction; Trough concentration |
| Core Tip |
In this retrospective study, we evaluated 12 adult chronic pulmonary aspergillosis patients who developed hepatotoxicity during voriconazole treatment. The hepatotoxicity is mainly manifested in a significant increase in the level of gamma-glutamyltransferase. In some patients, gamma-glutamyltransferase can reach up to 6-20 times to the upper limit. Overall findings recommend that reducing the lower limit of the voriconazole trough concentration to 0.5 µg/mL, can alleviate the hepatotoxicity of chronic pulmonary aspergillosis patients, and maintain the clinical efficacy. |
| Publish Date |
2020-10-26 09:59 |
| Citation |
Teng GJ, Bai XR, Zhang L, Liu HJ, Nie XH. Remission of hepatotoxicity in chronic pulmonary aspergillosis patients after lowering trough concentration of voriconazole. World J Clin Cases 2020; 8(20): 4700-4707 |
| URL |
https://www.wjgnet.com/2307-8960/full/v8/i20/4700.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v8.i20.4700 |
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