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Articles Published Processes
10/14/2020 11:33:23 AM | Browse: 683 | Download: 1338
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Received |
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2020-05-22 13:33 |
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Peer-Review Started |
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2020-05-21 21:38 |
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To Make the First Decision |
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Return for Revision |
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2020-05-29 03:07 |
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Revised |
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2020-06-10 21:29 |
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Second Decision |
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2020-08-25 00:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-08-25 22:36 |
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Articles in Press |
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2020-08-25 22:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-09-15 01:53 |
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Publish the Manuscript Online |
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2020-10-14 11:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Longitudinal decrease in platelet counts as a surrogate marker of liver fibrosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Neta Gotlieb, Naama Schwartz, Shira Zelber-Sagi, Gabriel Chodick, Varda Shalev and Oren Shibolet |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Oren Shibolet, MD, Academic Research, Director, Professor, Department of Gastroenterology and Hepatology, Tel-Aviv Sourasky Medical Center, No. 6 Weizmann Street, Tel Aviv 6423906, Israel. orensh@tlvmc.gov.il |
| Key Words |
Cirrhosis; Platelets; Count; Trend; Prediction; Range |
| Core Tip |
Cirrhosis is usually asymptomatic thus often diagnosed late when complications occur. Most non-invasive hepatic fibrosis scores (fibrosis-4, aspartate transaminase-to-platelet ratio index) incorporate platelets as a strong risk factor. However, the association between platelets average trends within the normal range and the risk of cirrhosis development is unknown. We found that up to 15 years before the diagnosis of cirrhosis, a progressive decline in platelet counts occurs, within the normal limits along with a gradual incline in FIB-4. The decline in platelet counts may alert of an early liver disease and may enable early therapeutic and preventive interventions before complications occur. |
| Publish Date |
2020-10-14 11:33 |
| Citation |
Gotlieb N, Schwartz N, Zelber-Sagi S, Chodick G, Shalev V, Shibolet O. Longitudinal decrease in platelet counts as a surrogate marker of liver fibrosis. World J Gastroenterol 2020; 26(38): 5849-5862 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i38/5849.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i38.5849 |
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