Publication Name	World Journal of Stem Cells
Manuscript ID	56906
Country	Japan

Received	2020-05-19 06:37
Peer-Review Started	2020-05-19 06:37
To Make the First Decision
Return for Revision	2020-06-05 18:33
Revised	2020-06-08 06:56
Second Decision	2020-07-29 11:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-08-01 21:37
Articles in Press	2020-08-01 21:37
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-08-05 17:33
Typeset the Manuscript	2020-08-26 08:00
Publish the Manuscript Online	2020-09-22 06:23

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Minireviews
Article Title	Mass acquisition of human periodontal ligament stem cells
Manuscript Source	Invited Manuscript
All Author List	Hidefumi Maeda
ORCID	Author(s) ORCID Number Hidefumi Maeda http://orcid.org/0000-0002-1347-995x
Funding Agency and Grant Number	Funding Agency Grant Number Japan Society for the Promotion of Science JP17H01598
Corresponding Author	Hidefumi Maeda, DDS, PhD, Chairman, Professor, Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 8128582, Japan. hide@dent.kyushu-u.ac.jp
Key Words	Induced pluripotent stem cells; Mesoderm specific transcript; Periodontal ligament stem cells; Periodontal tissue; Regenerative medicine; Semaphorin 3A
Core Tip	For patients with severe periodontitis, deep caries, and trauma, which can lead to tooth loss, the development of highly effective regenerative therapies for severely damaged periodontal tissue is an urgent concern. As one possible method to address this issue, cell-based therapy using periodontal ligament stem cells (PDLSCs) shows great promise. However, the number of PDLSCs present in vivo is too small for implementation of this method, and PDLSC isolation requires patients to undergo invasive surgery. In this review, ways to acquire large numbers of PDLSCs and advances in periodontal regenerative therapy during the past two decades are summarized.
Publish Date	2020-09-22 06:23
Citation	Maeda H. Mass acquisition of human periodontal ligament stem cells. World J Stem Cells 2020; 12(9): 1023-1031
URL	https://www.wjgnet.com/1948-0210/full/v12/i9/1023.htm
DOI	https://dx.doi.org/10.4252/wjsc.v12.i9.1023

Full Article (PDF)	WJSC-12-1023.pdf
Full Article (Word)	WJSC-12-1023.docx
Manuscript File	56906-Review-Filipodia.docx
Answering Reviewers	56906-Answering reviewers.pdf
Audio Core Tip	56906-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	56906-Conflict-of-interest statement.pdf
Copyright License Agreement	56906-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	56906-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	56906-Language certificate.pdf
Peer-review Report	56906-Peer-review(s).pdf
Scientific Misconduct Check	56906-Scientific misconduct check.pdf
Scientific Editor Work List	56906-Scientific editor work list.pdf
CrossCheck Report	56906-CrossCheck report.pdf