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Articles Published Processes
10/26/2020 12:01:04 PM | Browse: 843 | Download: 1365
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Received |
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2020-05-24 07:04 |
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Peer-Review Started |
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2020-05-24 07:04 |
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To Make the First Decision |
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Return for Revision |
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2020-08-22 21:15 |
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Revised |
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2020-08-29 13:33 |
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Second Decision |
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2020-09-22 11:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-09-22 20:17 |
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Articles in Press |
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2020-09-22 20:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-10-23 10:08 |
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Publish the Manuscript Online |
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2020-10-26 12:01 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Still 'dwelling in the possibility' — critical update on stem cell therapy for acute on chronic liver failure
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Cyriac Abby Philips and Philip Augustine |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Cyriac Abby Philips, MBBS, MD, Consultant Physician-Scientist, The Liver Unit and Monarch Liver Lab, Cochin Gastroenterology Group, Ernakulam Medical Center, NH Bypass, Palarivattom, Kochi 682025, Kerala, India. abbyphilips@gmail.com |
| Key Words |
Portal hypertension; Regenerative therapy; Mesenchymal stem cells; Liver failure; Sepsis; |
| Core Tip |
In patients with acute on chronic liver failure, the efficacy and safety of stem cell therapy remains unclear because there are few adequately powered, high-quality studies. Most studies in acute-on-chronic liver failure (ACLF) have been performed in Asian centers and in those with hepatitis B virus infection. Some studies have demonstrated improved short-term survival as well as liver disease severity and better hepatic synthetic and excretory functions. However, long term clinical efficacy and safety as well as ideal protocols for stem cell extraction, dose, duration, route, and type, in patients with ACLF remain unclear and requires sufficiently powered studies. |
| Publish Date |
2020-10-26 12:01 |
| Citation |
Philip CA, Augustine P. Still 'dwelling in the possibility' — critical update on stem cell therapy for acute on chronic liver failure. World J Stem Cells 2020; 12(10): 1124-1132 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i10/1124.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i10.1124 |
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