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Articles Published Processes
9/22/2020 6:23:06 AM | Browse: 664 | Download: 1534
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Received |
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2020-05-27 07:57 |
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Peer-Review Started |
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2020-05-27 07:58 |
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To Make the First Decision |
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Return for Revision |
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2020-06-15 18:32 |
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Revised |
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2020-06-23 04:45 |
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Second Decision |
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2020-07-16 12:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-07-19 20:39 |
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Articles in Press |
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2020-07-19 20:39 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-07-27 00:20 |
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Typeset the Manuscript |
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2020-09-08 05:03 |
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Publish the Manuscript Online |
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2020-09-22 06:23 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Senescent mesenchymal stem/stromal cells and restoring their cellular functions
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Qing-Shu Meng, Jing Liu, Lu Wei, Hui-Min Fan, Xiao-Hui Zhou and Xiao-Ting Liang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81500207 |
| National Natural Science Foundation of China |
81670458 |
| National Natural Science Foundation of China |
81470393 |
| Shanghai Municipal Health and Family Planning Commission |
ZY(2018‑2020)‑FWTX‑2007 |
| Shanghai Key Medical Discipline for Critical Care Medicine |
2017zz02017 |
| National Key Research and Development Program of China |
2017YFA0105600 |
| Major Program of Development Fund for Shanghai Zhangjiang National Innovtaion Demonstration Zone <Stem Cell Strategic Biobank and Stem Cell Clinical Technology Transformation Platform> |
ZJ2018-ZD-004 |
| Science and Technology Commission of Shanghai Municipality |
17431906600 |
| Top-level Clinical Discipline Project of Shanghai Pudong |
PWYgf2018-05 |
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| Corresponding Author |
Xiao-Ting Liang, MD, PhD, Research Fellow, Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, No. 150, Jimo Road, Shanghai 200120, China. liangxt@tongji.edu.cn |
| Key Words |
Mesenchymal stem cells; Senescence; Features; Function; Rejuvenation strategy; |
| Core Tip |
Mesenchymal stem cells (MSCs) administration is a promising therapeutic strategy for various human diseases. However, cell aging limits MSCs function and therapeutic properties via reducing their activities. We review the morphological changes, molecular expression alterations and functional degeneration of aged MSCs, and the effects of aged MSCs on immune cells and other target cells. Additionally, we summarize the strategies to rejuvenate aged MSCs to enhance their clinical potential. |
| Publish Date |
2020-09-22 06:23 |
| Citation |
Meng QS, Liu J, Wei L, Fan HM, Zhou XH, Liang XT. Senescent mesenchymal stem/stromal cells and restoring their cellular functions. World J Stem Cells 2020; 12(9): 966-985 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i9/966.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i9.966 |
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