Publication Name	World Journal of Gastroenterology
Manuscript ID	5723
Country	Austria

Received	2013-09-23 11:49
Peer-Review Started	2013-09-24 10:13
To Make the First Decision	2013-10-14 21:14
Return for Revision	2013-10-16 13:12
Revised	2013-10-21 17:40
Second Decision	2013-11-04 18:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-05 11:14
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-06 09:52
Publish the Manuscript Online	2013-12-18 10:00

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Lymph node staging in colorectal cancer: Old controversies and recent advances
Manuscript Source	Invited Manuscript
All Author List	Annika Resch and Cord Langner
Funding Agency and Grant Number
Corresponding Author	Cord Langner, MD, Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria. cord.langner@medunigraz.at
Key Words	Colon cancer; Rectum cancer; Tumor staging; Lymph node metastasis; Prognosis; Sentinel lymph node; Lymph node ratio; Extracapsular invasion; Immunohistochemistry; Molecular analysis
Core Tip	For patients with colorectal cancer, the indication for adjuvant therapy is mainly guided by the presence of regional lymph node metastasis. This review provides an in depth analysis of parameters affecting the clinical significance of lymph node staging, focusing on changing definitions of lymph nodes, involved lymph nodes, and tumor deposits in different editions of the American Joint Committee on Cancer/Union for International Cancer Control tumor node metastasis staging system, the minimum number of lymph nodes that should be evaluated, lymph node ratio, extracapsular invasion, sentinel node biopsy, and the potential benefit of ancillary techniques, such as immunohistochemistry and molecular analysis.
Publish Date	2013-12-18 10:00
Citation	Resch A, Langner C. Lymph node staging in colorectal cancer: Old controversies and recent advances. World J Gastroenterol 2013; 19(46): 8515-8526
URL	http://www.wjgnet.com/1007-9327/full/v19/i46/8515.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i46.8515

Full Article (PDF)	WJG-19-8515.pdf
Manuscript File	5723-Review.docx
Answering Reviewers	5723-Answering reviewers.pdf
Copyright License Agreement	5723-Copyright assignment.pdf
Peer-review Report	5723-Peer reviews.pdf
Scientific Editor Work List	5723-Scientific editor work list.doc