Publication Name	World Journal of Gastroenterology
Manuscript ID	5729
Country	Japan

Received	2013-09-25 08:09
Peer-Review Started	2013-09-25 10:54
To Make the First Decision	2013-12-26 10:57
Return for Revision	2014-01-17 10:22
Revised	2014-02-09 15:12
Second Decision	2014-02-20 15:16
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-20 16:06
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-03 10:43
Publish the Manuscript Online	2014-03-12 14:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Management of thrombocytopenia due to liver cirrhosis: A review
Manuscript Source	Invited Manuscript
All Author List	Hiromitsu Hayashi, Toru Beppu, Ken Shirabe, Yoshihiko Maehara and Hideo Baba
Funding Agency and Grant Number	Funding Agency Grant Number Grant-in-Aid for Young Scientists, Ministry of Education, Culture, Sports, Science and Technology of Japan 24791434 (to Hayashi H) Takeda Science Foundation, Japan to Hayashi H
Corresponding Author	Hideo Baba, MD, PhD, FACS, Professor, Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan. hdobaba@kumamoto-u.ac.jp
Key Words	Liver cirrhosis; Thrombocytopenia; Thrombopoietin; Partial splenic embolization; Splenectomy
Core Tip	The major mechanisms for thrombocytopenia in liver cirrhosis are (1) platelet sequestration in the spleen; and (2) decreased production of thrombopoietin in the liver. For thrombocytopenia that is caused by platelet sequestration in the spleen, partial splenic embolization or laparoscopic splenectomy are effective. Thrombopoietin agonists and targeted agents are alternative tools for noninvasively treating thrombocytopenia due to decreased thrombopoietin production, although their ability to improve thrombocytopenia is under investigation in clinical trials. In this review, we describe the current management of thrombocytopenia due to liver cirrhosis, and we propose the novel concept of using the splenic volume to discern the primary cause of thrombocytopenia due to liver cirrhosis.
Publish Date	2014-03-12 14:46
Citation	Hayashi H, Beppu T, Shirabe K, Maehara Y, Baba H. Management of thrombocytopenia due to liver cirrhosis: A review. World J Gastroenterol 2014; 20(10): 2595-2605
URL	http://www.wjgnet.com/1007-9327/full/v20/i10/2595.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i10.2595

Full Article (PDF)	WJG-20-2595.pdf
Full Article (Word)	WJG-20-2595.doc
Manuscript File	5729-Review.docx
Answering Reviewers	5729-Answering reviewers.pdf
Copyright License Agreement	5729-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5729-Language certificate.pdf
Peer-review Report	5729-Peer reviews.pdf
Scientific Editor Work List	5729-Scientific editor work list.doc