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Articles Published Processes
9/10/2020 5:57:28 AM | Browse: 590 | Download: 941
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Received |
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2020-06-03 07:56 |
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Peer-Review Started |
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2020-06-03 07:57 |
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To Make the First Decision |
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Return for Revision |
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2020-07-21 16:55 |
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Revised |
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2020-08-03 11:00 |
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Second Decision |
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2020-08-25 08:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-08-26 04:42 |
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Articles in Press |
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2020-08-26 04:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-09-01 11:42 |
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Publish the Manuscript Online |
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2020-09-10 05:57 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Notch signalling pathway in development of cholangiocarcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bisma Rauff, Arif Malik, Yasir Ali Bhatti, Shafiq Ahmad Chudhary, Ishtiaq Qadri and Shafquat Rafiq |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Bisma Rauff, PhD, Assistant Professor, Institute of Molecular Biology and Biotechnology, University of Lahore, 1-Km Defence Road، Near Bhuptian Chowk, Lahore 54000, Pakistan. bisma.rauff@imbb.uol.edu.pk |
| Key Words |
Cholangicarcinoma; Notch receptors; Therapeutic targets; Notch signalling pathway; Gamma secretase inhibitor; Cholangiocytes |
| Core Tip |
In this review, we explore current findings on the Notch signalling pathway, its molecular components, its specific roles in the development and progression of cholangiocarcinma (CCA), the treatment approaches aimed at suppressing this signaling pathway, and discuss the encouraging results presented by basic science research and preclinical trials. The Notch signaling pathway is a key driver of cholangiocarcinogenesis and represents a promising therapeutic target in CCA. A wide and comprehensive understanding of the molecular mechanisms triggered by the pathway will help us explore novel therapies against CCA. |
| Publish Date |
2020-09-10 05:57 |
| Citation |
Rauff B, Malik A, Ali Y, Chudhary SA, Qadri I, Rafiq S. Notch signalling pathway in development of cholangiocarcinoma. World J Gastrointest Oncol 2020; 12(9): 957-974 |
| URL |
https://www.wjgnet.com/1948-5204/full/v12/i9/957.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v12.i9.957 |
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