Publication Name	World Journal of Gastroenterology
Manuscript ID	5741
Country	Germany

Received	2013-10-03 19:37
Peer-Review Started	2013-10-04 16:36
To Make the First Decision	2013-11-12 21:09
Return for Revision	2013-11-19 13:24
Revised	2013-12-06 22:24
Second Decision	2014-01-15 20:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-15 20:35
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-19 18:45
Publish the Manuscript Online	2014-02-26 11:18

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Targeting cell death signaling in colorectal cancer: Current strategies and future perspectives
Manuscript Source	Invited Manuscript
All Author List	Bruno Christian Koehler, Dirk Jäger and Henning Schulze-Bergkamen
Funding Agency and Grant Number
Corresponding Author	Henning Schulze-Bergkamen, MD, National Center for Tumor Diseases, University Hospitals Heidelberg, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany. henning.schulze@med.uni-heidelberg.de
Key Words	Colorectal cancer; Apoptosis; Necroptosis; Autophagy; Clinical trial; Bcl-2 proteins; BH-3 mimetics; Inflammatory bowel disease
Core Tip	This review highlights current strategies targeting cell death signaling in colorectal cancer. The role of apoptosis, autophagy and necroptosis in the normal colon mucosa as well as in colorectal cancer onset and therapy is defined. Relevant small molecule compounds as well as antisense based approaches for the treatment of colorectal cancer are illustrated. Furthermore, clinical trials investigating new cell death based compounds are discussed. Finally, future directions in translational cell death research are discussed.
Publish Date	2014-02-26 11:18
Citation	Koehler BC, J?ger D, Schulze-Bergkamen H. Targeting cell death signaling in colorectal cancer: Current strategies and future perspectives. World J Gastroenterol 2014; 20(8): 1923-1934
URL	http://www.wjgnet.com/1007-9327/full/v20/i8/1923.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i8.1923

Full Article (PDF)	WJG-20-1923.pdf
Full Article (Word)	WJG-20-1923.doc
Manuscript File	5741-Review.doc
Answering Reviewers	5741-Answering reviewers.pdf
Copyright License Agreement	5741-Copyright assignment.pdf
Peer-review Report	5741-Peer reviews.pdf
Scientific Editor Work List	5741-Scientific editor work list.doc