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9/2/2014 3:20:00 PM | Browse: 856 | Download: 295
Publication Name World Journal of Gastroenterology
Manuscript ID 5741
Country/Territory Germany
Received
2013-10-03 19:37
Peer-Review Started
2013-10-04 16:36
To Make the First Decision
2013-11-12 21:09
Return for Revision
2013-11-19 13:24
Revised
2013-12-06 22:24
Second Decision
2014-01-15 20:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-01-15 20:35
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-02-19 18:45
Publish the Manuscript Online
2014-02-26 11:18
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Topic Highlights
Article Title Targeting cell death signaling in colorectal cancer: Current strategies and future perspectives
Manuscript Source Invited Manuscript
All Author List Bruno Christian Koehler, Dirk Jäger and Henning Schulze-Bergkamen
Funding Agency and Grant Number
Corresponding author Henning Schulze-Bergkamen, MD, National Center for Tumor Diseases, University Hospitals Heidelberg, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany. henning.schulze@med.uni-heidelberg.de
Keywords Colorectal cancer; Apoptosis; Necroptosis; Autophagy; Clinical trial; Bcl-2 proteins; BH-3 mimetics; Inflammatory bowel disease
Core Tip This review highlights current strategies targeting cell death signaling in colorectal cancer. The role of apoptosis, autophagy and necroptosis in the normal colon mucosa as well as in colorectal cancer onset and therapy is defined. Relevant small molecule compounds as well as antisense based approaches for the treatment of colorectal cancer are illustrated. Furthermore, clinical trials investigating new cell death based compounds are discussed. Finally, future directions in translational cell death research are discussed.
Publish Date 2014-02-26 11:18
Citation Koehler BC, J?ger D, Schulze-Bergkamen H. Targeting cell death signaling in colorectal cancer: Current strategies and future perspectives. World J Gastroenterol 2014; 20(8): 1923-1934
Url http://www.wjgnet.com/1007-9327/full/v20/i8/1923.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i8.1923
Full Article (PDF) WJG-20-1923.pdf
Full Article (Word) WJG-20-1923.doc
Manuscript File 5741-Review.doc
Answering Reviewers 5741-Answering reviewers.pdf
Copyright License Agreement 5741-Copyright assignment.pdf
Peer-review Report 5741-Peer reviews.pdf
Scientific Editor Work List 5741-Scientific editor work list.doc