Publication Name	World Journal of Diabetes
Manuscript ID	5746
Country	Japan

Received	2013-09-25 09:28
Peer-Review Started	2013-09-25 12:12
To Make the First Decision	2013-10-18 12:50
Return for Revision	2013-10-18 12:55
Revised	2013-10-19 12:50
Second Decision	2013-11-15 18:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-16 01:00
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-21 14:22
Typeset the Manuscript	2013-12-05 15:01
Publish the Manuscript Online	2013-12-20 16:49

ISSN	1948-9358 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Ophthalmology
Manuscript Type	Topic Highlights
Article Title	Therapeutic effects of sericin on diabetic keratopathy in Otsuka Long-Evans Tokushima Fatty rats
Manuscript Source	Invited Manuscript
All Author List	Noriaki Nagai and Yoshimasa Ito
Funding Agency and Grant Number
Corresponding Author	Yoshimasa Ito, PhD, Faculty of Pharmacy, Kinki University, Higashi-Osaka, Osaka 577-8502, Japan. itoyoshi@phar.kindai.ac.jp
Key Words	Sericin; Diabetic keratopathy; Cornea; Type 2 diabetes mellitus; Otsuka Long-Evans Tokushima Fatty rat
Core Tip	Otsuka Long-Evans Tokushima Fatty (OLETF) rats provide a useful model for studies to develop corneal wound healing drugs for use in diabetic keratopathy resulting from type 2 diabetes mellitus. The present study demonstrates that the rate of corneal wound healing in OLETF rats is slower than in normal rat, probably due to the suppression of cell migration and proliferation caused by high plasma glucose levels. The instillation of sericin has a potent effect in promoting wound healing and wound size reduction in OLETF rats. The sericin may be an effective and safe drug to promote corneal wound healing in diabetic keratopathy.
Publish Date	2013-12-20 16:49
Citation	Nagai N, Ito Y. Therapeutic effects of sericin on diabetic keratopathy in Otsuka Long-Evans Tokushima Fatty rats. World J Diabetes 2013; 4(6): 282-289 Available from: URL: http://www.wjgnet.com/1948-9358/full/v4/i6/282.htm DOI: http://dx.doi.org/10.4239/wjd.v4.i6.282
URL	http://www.wjgnet.com/1948-9358/full/v4/i6/282.htm
DOI	http://dx.doi.org/10.4239/wjd.v4.i6.282

Full Article (PDF)	WJD-4-282.pdf
Full Article (Word)	WJD-4-282.doc
Manuscript File	5746-Review.docx
Answering Reviewers	5746-Answering reviewers.pdf
Copyright License Agreement	5746-Copyright assignment.pdf
Peer-review Report	5746-Peer reviews.pdf
Scientific Editor Work List	5746-Scientific editor work list.doc