Publication Name	World Journal of Gastroenterology
Manuscript ID	5750
Country	South Korea

Received	2013-09-25 10:03
Peer-Review Started	2013-09-25 16:11
To Make the First Decision	2013-10-14 21:13
Return for Revision	2013-10-16 13:25
Revised	2013-10-24 09:18
Second Decision	2013-11-04 18:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-11-05 11:17
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-10 15:01
Publish the Manuscript Online	2014-01-19 14:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Hepatitis B virus mutations related to liver disease progression of Korean patients
Manuscript Source	Invited Manuscript
All Author List	Bum-Joon Kim
Funding Agency and Grant Number	Funding Agency Grant Number National Research Foundation of Korea grant funded by the Korean government (MEST) 2013005810
Corresponding Author	Bum-Joon Kim, PhD, Department of Biomedical Sciences, Microbiology and Immunology, Liver Research Institute, and Cancer Research Institute, College of Medicine, Seoul National University, 28 Yongon-dong, Chongno-gu, Seoul 110-799, South Korea. kbumjoon@snu.ac.kr
Key Words	Hepatitis B virus; Mutation; South Korea; Hepatocellular carcinoma; Genotype C2
Core Tip	In this review paper, we summarize the distinct hepatitis B virus (HBV) mutation patterns related to clinical severity and the molecular epidemiologic traits in Korean chronic patients based on previous reports. Generally, several lines of evidence have led to the conclusion that a combination of the exclusive predominance of genotype C2, which is prone to mutations, the high prevalence of basal core promoter double mutations, and the presence of distinct immune responses against HBV proteins in the Korean population may generate the distinct HBV variants rarely or not encountered in other areas, which results in distinct clinical manifestations in Korean chronic patients.
Publish Date	2014-01-19 14:17
Citation	Kim BJ. Hepatitis B virus mutations related to liver disease progression of Korean patients. World J Gastroenterol 2014; 20(2): 460-467
URL	http://www.wjgnet.com/1007-9327/full/v20/i2/460.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i2.460

Full Article (PDF)	WJG-20-460.pdf
Full Article (Word)	WJG-20-460.doc
Manuscript File	5750-Review.doc
Answering Reviewers	5750-Answering reviewers.pdf
Copyright License Agreement	5750-Copyright assignment.pdf
Peer-review Report	5750-Peer reviews.pdf
Scientific Editor Work List	5750-Scientific editor work list.doc