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Articles Published Processes
11/24/2020 12:41:21 PM | Browse: 671 | Download: 1588
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Received |
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2020-06-15 18:12 |
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Peer-Review Started |
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2020-06-15 18:14 |
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To Make the First Decision |
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Return for Revision |
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2020-06-20 21:28 |
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Revised |
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2020-07-23 10:53 |
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Second Decision |
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2020-09-15 00:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-09-15 17:37 |
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Articles in Press |
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2020-09-15 17:37 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-11-17 09:01 |
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Publish the Manuscript Online |
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2020-11-24 12:41 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Inhibition of vascular adhesion protein-1 modifies hepatic steatosis in vitro and in vivo
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Emma L Shepherd, Sumera Karim, Philip N Newsome and Patricia F Lalor |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Patricia F Lalor, BSc, PhD, Academic Research, Reader (Associate Professor), Centre for Liver and Gastroenterology Research, Birmingham National Institute for Health Research, Birmingham Biomedical Research Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, West Midlands, United Kingdom. p.f.lalor@bham.ac.uk |
| Key Words |
Non-alcoholic fatty liver disease; Hepatocyte; Lipid; Cell biology; Vascular adhesion protein-1; Steatosis |
| Core Tip |
Incidence of non-alcoholic fatty liver disease (NAFLD) is dramatically increasing worldwide but to date there are no licenced therapies. The challenge remains management of the diverse pathophysiology from simple steatosis, through inflammation and fibrosis and the systemic complications of the metabolic syndrome. Vascular adhesion protein-1 (VAP-1) is an enzyme with proven contributions to systemic and hepatic glucose handling, inflammation and fibrosis. We now show an additional role in hepatic steatosis. Thus our important data suggests that targeting the semicarbazide sensitive amine oxidase capacity of VAP-1 may represent a useful adjunct to other therapeutic strategies in NAFLD. |
| Publish Date |
2020-11-24 12:41 |
| Citation |
Shepherd EL, Karim S, Newsome PN, Lalor PF. Inhibition of vascular adhesion protein-1 modifies hepatic steatosis in vitro and in vivo. World J Hepatol 2020; 12(11): 931-948 |
| URL |
https://www.wjgnet.com/1948-5182/full/v12/i11/931.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v12.i11.931 |
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