| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Observational Study |
| Article Title |
Factors predisposing to thrombosis after major joint arthroplasty
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Zoe H Dailiana, Nikolaos Stefanou, Sokratis Varitimids, Nikolaos Rigopoulos, Apostolos Dimitroulias, Theofilos Karachalios, Konstantinos N Malizos, Despoina Kyriakou and Panagoula Kollia |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Hellenic Association of Orthopaedic Surgery and Traumatology |
EEXOT 20022007 |
|
| Corresponding Author |
Zoe H Dailiana, MD, PhD, Professor, Surgeon, Department of Orthopaedic Surgery, Faculty of Medicine, School of Health Sciences, University of Thessaly, 3 Panepistimiou Street, Biopolis, Larissa 41500, Greece. dailiana@med.uth.gr |
| Key Words |
Arthroplasty; Thrombosis; Heparin-induced thrombocytopenia; Coagulation factors; Low-molecular-weight-heparin; Fondaparinux |
| Core Tip |
This is a prospective study aiming to evaluate the impact of genetic profile of patients and pharmacologic factors (anticoagulant chemoprophylaxis with LMWH or fondaparinux) on the development of thrombosis (including heparin-induced thrombocytopenia/thrombosis [HIT/T]) after lower limb arthroplasty. Thrombosis was related to the development of anti-PF4/heparin antibodiesand was correlated significantly to factor II and V mutations.Thus, screening of coagulation profile preoperatively could minimize the risk of post-arthroplasty thrombosis. Platelet monitoring does not uncover all cases of anti-PF4/heparin antibodiesformation, while antibodymonitoring post-anticoagulant administration, is probably unnecessary. Fondaparinux can lead to the formation of anti-PF4/heparin antibodies and may cause HIT. |
| Publish Date |
2020-09-15 04:38 |
| Citation |
Dailiana ZH, Stefanou N, Varitimids S, Rigopoulos N, Dimitroulias A, Karachalios T, Malizos KN, Kyriakou D, Kollia P. Factors predisposing to thrombosis after major joint arthroplasty. World J Orthop 2020; 11(9): 400-410 |
| URL |
https://www.wjgnet.com/2218-5836/full/v11/i9/400.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v11.i9.400 |
