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12/27/2020 5:30:53 AM | Browse: 1225 | Download: 2735
Publication Name World Journal of Stem Cells
Manuscript ID 57595
Country China
Received
2020-06-16 04:00
Peer-Review Started
2020-06-16 04:01
First Decision by Editorial Office Director
2020-09-18 16:57
Return for Revision
2020-09-18 16:57
Revised
2020-09-28 03:45
Publication Fee Transferred
Second Decision by Editor
2020-10-23 10:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2020-10-26 16:54
Articles in Press
2020-10-26 16:54
Edit the Manuscript by Language Editor
2020-11-13 04:02
Typeset the Manuscript
2020-12-24 08:00
Publish the Manuscript Online
2020-12-27 05:30
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Review
Article Title Effect of metformin on stem cells: Molecular mechanism and clinical prospect
Manuscript Source Invited Manuscript
All Author List Lin-Li Jiang and Lei Liu
ORCID
Author(s) ORCID Number
Lin-Li Jiang http://orcid.org/0000-0002-8283-3457
Lei Liu http://orcid.org/0000-0001-5309-1979
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81670951
Corresponding Author Lei Liu, MD, PhD, Professor, Department of State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Oral and Maxillofacial Surgery Department, West China Hospital of Stomatology, Sichuan University, No. 14 Section 3 Renmin South Road, Chengdu 610041, Sichuan Province, China. drliulei@163.com
Key Words Metformin; Stem cells; Differentiation; Anti-aging; Anti-cancer; Mechanism
Core Tip The effect of metformin on stem cells is quickly gaining attention. Because metformin modulates various physiological activities and pathological changes via targeting stem cells. Emerging studies suggest that metformin has broad prospects in the fields of stem cell medicine, gerontology, regenerative medicine, and cancer therapy, etc. In this review, we summarize the effects of metformin on stem cells and provide an overview of its molecular mechanisms and clinical prospects.
Publish Date 2020-12-27 05:30
Citation Jiang LL, Liu L. Effect of metformin on stem cells: Molecular mechanism and clinical prospect. World J Stem Cells 2020; 12(12): 1455-1473
URL https://www.wjgnet.com/1948-0210/full/v12/i12/1455.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i12.1455
Full Article (PDF) WJSC-12-1455.pdf
Full Article (Word) WJSC-12-1455.docx