Publication Name	World Journal of Gastroenterology
Manuscript ID	5763
Country	Italy

Received	2013-09-25 13:05
Peer-Review Started	2013-09-25 16:39
To Make the First Decision	2013-12-03 19:13
Return for Revision	2013-12-13 15:35
Revised	2014-01-13 19:42
Second Decision	2014-04-03 10:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-03 12:25
Articles in Press	2014-05-23 12:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-29 20:55
Publish the Manuscript Online	2014-06-16 16:19

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Hepatic flares in chronic hepatitis C: Spontaneous exacerbation vs hepatotropic viruses superinfection
Manuscript Source	Invited Manuscript
All Author List	Evangelista Sagnelli, Caterina Sagnelli, Mariantonietta Pisaturo and Nicola Coppola
Funding Agency and Grant Number	Funding Agency Grant Number PRIN 2008 “Ottimizzazione Della Diagnosi Eziologica dell’epatite Acuta C E Studio dei Fattori Viro-Immunologici di Guarigione, di Cronicizzazione E di Risposta Alla Terapia Con Interferone” Regione Campania “Progetti per il miglioramento della qualità dell’assistenza, diagnosi e terapia del paziente affetto da AIDS nei settori: immunologia, coinfezioni, informazione e prevenzione” 2008
Corresponding Author	Evangelista Sagnelli, Professor, Section of Infectious Diseases, Department of Mental Health and Public Medicine, Second University of Naples, Vico Luigi de Crecchio, 16, 80131 Naples, Italy. evangelista.sagnelli@unina2.it
Key Words	Chronic hepatitis C virus infection; Hepatic flares; Hepatic flares in immunocompromised patients; Immunocompromised patients; Hepatitis A virus superinfection
Core Tip	Patients with chronic hepatitis C virus infection may experience hepatic flares due to an acute exacerbation of this disease that is frequently characterized by a significant increase in liver fibrosis and necroinflammation but by a high rate of sustained viral response to Peg-interferon plus ribavirin treatment. A hepatic flare may also be due to superinfection by other hepatotropic viruses, drug injury or a concomitant autoimmune disease. The aim of this review is to be of some help in identifying the cause of the flare in a single patient in order to optimize the follow-up and clinical and therapeutic decisions.
Publish Date	2014-06-16 16:19
Citation	Sagnelli E, Sagnelli C, Pisaturo M, Coppola N. Hepatic flares in chronic hepatitis C: Spontaneous exacerbation vs hepatotropic viruses superinfection. World J Gastroenterol 2014; 20(22): 6707-6715
URL	http://www.wjgnet.com/1007-9327/full/v20/i22/6707.htm
DOI	10.3748/wjg.v20.i22.6707

Full Article (PDF)	WJG-20-6707.pdf
Full Article (Word)	WJG-20-6707.doc
Manuscript File	5763-Review.docx
Answering Reviewers	5763-Answering reviewers.pdf
Copyright License Agreement	5763-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5763-Language certificate.pdf
Peer-review Report	5763-Peer reviews.pdf
Scientific Editor Work List	5763-Scientific editor work list.doc