Publication Name	World Journal of Gastroenterology
Manuscript ID	5767
Country	Poland

Received	2013-09-25 13:19
Peer-Review Started	2013-09-25 16:51
To Make the First Decision	2013-11-21 20:59
Return for Revision	2013-11-22 09:22
Revised	2013-12-10 02:50
Second Decision	2014-01-15 20:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-15 20:36
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-05 09:43
Publish the Manuscript Online	2014-03-12 14:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Sex hormones in the modulation of irritable bowel syndrome
Manuscript Source	Invited Manuscript
All Author List	Agata Mulak, Yvette Taché and Muriel Larauche
Funding Agency and Grant Number	Funding Agency Grant Number Veterans Administration Research Career Scientist Award to Taché Y National Institute of Health P50 DK-64539 (to Taché Y) National Institute of Health K01-DK088937 (to Larauche M)
Corresponding Author	Agata Mulak, MD, PhD, Department of Gastroenterology and Hepatology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland. agata.mulak@wp.pl
Key Words	Brain-gut axis; Irritable bowel syndrome; Microbiota; Pain modulation; Sex hormones
Core Tip	Recent clinical and experimental findings support the modulatory actions of sex hormones exerted at different levels of the brain-gut-microbiota axis in irritable bowel syndrome (IBS). Sex hormones may influence peripheral and central regulatory mechanisms contributing to the alterations in visceral sensitivity, motility, permeability, and immune activation of intestinal mucosa. A new concept of “microgenderome” is emerging based on the observations that the gender bias present in numerous diseases may be reinforced by the commensal microbiota of the host. Significant sex differences in epidemiology, symptomatology, and treatment outcome in IBS indicate the necessity for sex-tailored therapeutic approach in this disorder.
Publish Date	2014-03-12 14:46
Citation	Mulak A, Taché Y, Larauche M. Sex hormones in the modulation of irritable bowel syndrome. World J Gastroenterol 2014; 20(10): 2433-2448
URL	http://www.wjgnet.com/1007-9327/full/v20/i10/2433.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i10.2433

Full Article (PDF)	WJG-20-2433.pdf
Full Article (Word)	WJG-20-2433.doc
Manuscript File	5767-Review.doc
Answering Reviewers	5767-Answering reviewers.pdf
Copyright License Agreement	5767-Copyright assignment.pdf
Peer-review Report	5767-Peer reviews.pdf
Scientific Editor Work List	5767-Scientific editor work list.doc