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Articles Published Processes
12/27/2020 5:30:53 AM | Browse: 647 | Download: 962
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Received |
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2020-06-23 08:14 |
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Peer-Review Started |
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2020-06-23 08:15 |
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To Make the First Decision |
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Return for Revision |
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2020-07-30 23:02 |
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Revised |
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2020-08-13 07:20 |
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Second Decision |
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2020-09-25 09:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-09-25 19:02 |
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Articles in Press |
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2020-09-25 19:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-12-24 00:44 |
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Publish the Manuscript Online |
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2020-12-27 05:30 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Novel insights for improving the therapeutic safety and efficiency of mesenchymal stromal cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mehdi Najar, Johanne Martel-Pelletier, Jean Pierre Pelletier and Hassan Fahmi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| La Chaire en Arthrose de l’Université de Montréal |
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| Corresponding Author |
Mehdi Najar, PhD, Academic Fellow, Department of Medicine, University of Montreal, Osteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), 900 Saint-Denis Street, R Tower, 11th floor, Montreal H2X 0A9, QC, Canada. mnajar@ulb.ac.be |
| Key Words |
Cell-therapy; Mesenchymal stromal cells; Safety; Extracellular vesicles; Efficiency; Preconditioning |
| Core Tip |
Mesenchymal stromal cells (MSCs) have a strong capacity to regenerate injured tissues by displaying trophic and immunomodulatory functions. The tissue environment plays a significant role during the reparative process of MSCs. Preconditioning of MSCs with a specific signal promotes the adequate response. As the therapeutic functions of MSCs are mainly linked to their secretome, the use of extracellular vesicles as an acellular tool is strongly recommended. Thus, new insights on the properties of MSCs as well as their mechanisms of actions will help to develop a safe and efficient therapeutic strategy. |
| Publish Date |
2020-12-27 05:30 |
| Citation |
Najar M, Martel-Pelletier J, Pelletier JP, Fahmi H. Novel insights for improving the therapeutic safety and efficiency of mesenchymal stromal cells. World J Stem Cells 2020; 12(12): 1474-1491 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i12/1474.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i12.1474 |
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