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Articles Published Processes
12/4/2020 9:57:00 AM | Browse: 629 | Download: 986
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Received |
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2020-06-28 02:32 |
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Peer-Review Started |
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2020-06-28 02:32 |
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To Make the First Decision |
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Return for Revision |
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2020-09-29 19:15 |
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Revised |
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2020-10-13 15:10 |
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Second Decision |
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2020-10-26 11:10 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-10-26 21:38 |
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Articles in Press |
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2020-10-26 21:38 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-11-10 07:24 |
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Typeset the Manuscript |
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2020-11-30 04:45 |
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Publish the Manuscript Online |
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2020-12-04 09:57 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Hematology |
| Manuscript Type |
Case Report |
| Article Title |
Hemophagocytic lymphohistiocytosis caused by STAT1 gain-of-function mutation is not driven by interferon-γ: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Nan Liu, Fen-Ying Zhao and Xiao-Jun Xu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xiao-Jun Xu, PhD, Chief Doctor, Division of Hematology-oncology, Children’s Hospital, Zhejiang University School of Medicine, No. 57 Zhuganxiang Road, Yan-an Street, Hangzhou 310003, Zhejiang Province, China. xuxiaojun@zju.edu.cn |
| Key Words |
Hemophagocytic lymphohistiocytosis; Signal transducer and activator of transcription 1; Gain-of-function; Interferon gama; Mycobacterial disease; Case report |
| Core Tip |
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome caused by many genetic defects. Cytokine storm is frequent and interferon (IFN)-γ is considered to play a key role. We present a case of HLH caused by STAT1 gain-of-function (GOF) mutation. The cytokine profile showed moderately elevated interleukin (IL)-6 and IL-10 and normal IFN-γ. In STAT1 GOF mutation, although inhibition of IL-12R/IL-23R signaling leads to diminished T helper (Th) 1/Th17 and IL-12 response, which then prevent a cytokine storm, overactivity of phagocytic cells due to hyperphosphorylation of STAT1 can lead to HLH. |
| Publish Date |
2020-12-04 09:57 |
| Citation |
Liu N, Zhao FY, Xu XJ. Hemophagocytic lymphohistiocytosis caused by STAT1 gain-of-function mutation is not driven by interferon-γ: A case report. World J Clin Cases 2020; 8(23): 6130-6135 |
| URL |
https://www.wjgnet.com/2307-8960/full/v8/i23/6130.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v8.i23.6130 |
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