| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
New strain of Pediococcus pentosaceus alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xian-Wan Jiang, Ya-Ting Li, Jian-Zhong Ye, Long-Xian Lv, Li-Ya Yang, Xiao-Yuan Bian, Wen-Rui Wu, Jing-Jing Wu, Ding Shi, Qing Wang, Dai-Qiong Fang, Kai-Cen Wang, Qiang-Qiang Wang, Yan-Meng Lu, Jiao-Jiao Xie and Lan-Juan Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81330011, 81790631, 81570512, and 81790633 |
| Science Fund for Creative Research Groups of the National Natural Science Foundation of China |
81121002 |
| National Key Research and Development Program of China |
2018YFC2000500 |
|
| Corresponding Author |
Lan-Juan Li, PhD, Academic Research, Doctor, Professor, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. ljli@zju.edu.cn |
| Key Words |
Pediococcus pentosaceus; Alcoholic liver disease; Gut microbiota; Probiotic; Short-chain fatty acid; |
| Core Tip |
Gut microbiota dysbiosis plays an important role in the progression of ethanol-induced liver injury, but an effective microbe-based therapy is lacking. Our study screened an ethanol-resistant strain of Pediococcus pentosaceus as a potential probiotic. Preliminary results indicated that the new strain of Pediococcus pentosaceus modulated the composition of the gut microbiota and short-chain fatty acid metabolism to protect against ethanol-induced liver injury in a mouse model. |
| Publish Date |
2020-10-28 08:26 |
| Citation |
Jiang XW, Li YT, Ye JZ, Lv LX, Yang LY, Bian XY, Wu WR, Wu JJ, Shi D, Wang Q, Fang DQ, Wang KC, Wang QQ, Lu YM, Xie JJ, Li LJ. New strain of Pediococcus pentosaceus alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism. World J Gastroenterol 2020; 26(40): 6224-6240 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i40/6224.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i40.6224 |
