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Articles Published Processes
1/15/2021 11:46:51 AM | Browse: 555 | Download: 1193
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Received |
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2020-06-24 17:43 |
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Peer-Review Started |
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2020-06-24 17:44 |
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To Make the First Decision |
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Return for Revision |
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2020-11-04 17:43 |
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Revised |
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2020-11-17 21:02 |
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Second Decision |
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2020-12-30 08:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-12-30 15:30 |
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Articles in Press |
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2020-12-30 15:30 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-01-15 03:03 |
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Publish the Manuscript Online |
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2021-01-15 11:46 |
| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Inhibition of matrix metalloproteinase-9 secretion by dimethyl sulfoxide and cyclic adenosine monophosphate in human monocytes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Darcy R Denner, Maria LD Udan-Johns and Michael R Nichols |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Michael R Nichols, PhD, Professor, Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Blvd, St Louis, MO 63121, United States. nicholsmic@umsl.edu |
| Key Words |
Matrix metalloproteinase-9; Inflammation; Human monocytes; Tumor necrosis factor alpha; Cyclic adenosine monophosphate; Dimethyl sulfoxide |
| Core Tip |
This article describes the stimulation of matrix metalloproteinase-9 (MMP-9) and tumor necrosis factor α (TNFα) secretion from human monocyte cells by lipopolysaccharide, and the inhibition of this process by dimethyl sulfoxide and increased intracellular levels of 3',5'-cyclic adenosine monophosphate. The experimental findings demonstrated that dimethyl sulfoxide concentration must be carefully controlled in inflammatory studies, that MMP-9 secretion occurred downstream from TNFα secretion and that the two processes were distinct, and that TNFα is an integral component of the pathway leading to MMP-9 secretion. |
| Publish Date |
2021-01-15 11:46 |
| Citation |
Denner DR, Udan-Johns ML, Nichols MR. Inhibition of matrix metalloproteinase-9 secretion by dimethyl sulfoxide and cyclic adenosine monophosphate in human monocytes. World J Biol Chem 2021; 12(1): 1-14 |
| URL |
https://www.wjgnet.com/1949-8454/full/v12/i1/1.htm |
| DOI |
https://dx.doi.org/10.4331/wjbc.v12.i1.1 |
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