Publication Name	World Journal of Gastroenterology
Manuscript ID	5784
Country	South Korea

Received	2013-09-25 22:14
Peer-Review Started	2013-09-27 08:30
First Decision by Editorial Office Director
Return for Revision	2014-01-20 09:21
Revised	2014-01-30 13:46
Publication Fee Transferred
Second Decision by Editor	2014-02-20 15:16
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-02-20 16:06
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-04-11 10:16
Publish the Manuscript Online	2014-04-17 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Jung Ho Kim and Gyeong Hoon Kang
Funding Agency and Grant Number	Funding Agency Grant Number National R&D Program for Cancer Control funded by the Ministry of Health and Welfare, South Korea 0720540 National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) 2011-0030768 Priority Research Centers Program through the NRF grant funded by the Ministry of Education, Science and Technology (MEST), South Korea 2009-0093820 Mid-career Researcher Program through the NRF grant funded by MEST 2011-0015646
Corresponding Author	Gyeong Hoon Kang, MD, PhD, Professor, Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, South Korea. ghkang@snu.ac.kr
Key Words	Colorectal cancer; Microsatellite instability; DNA mismatch repair; DNA methylation; CpG islands; Prognosis; Adjuvant chemotherapy
Core Tip	A high level of microsatellite instability (MSI-H) is a known molecular indicator of a favorable prognosis and low benefit of 5-fluorouracil-based adjuvant chemotherapy in patients with colorectal cancer (CRC). However, MSI-H CRCs are molecularly heterogeneous tumors, which are characterized by DNA mismatch repair deficiency and various genetic and epigenetic alterations. Therefore, we hypothesized that MSI-H CRCs can be divided into prognostic subgroups based on the molecular heterogeneity. This article provides an up-to-date review concerning the underlying molecular features of MSI-H CRCs and potential prognostic or predictive molecular markers for MSI-H CRCs.
Publish Date	2014-04-17 13:27
Citation	Kim JH, Kang GH. Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer. World J Gastroenterol 2014; 20(15): 4230-4243
URL	http://www.wjgnet.com/1007-9327/full/v20/i15/4230.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i15.4230

Full Article (PDF)	WJG-20-4230.pdf
Full Article (Word)	WJG-20-4230.doc
Manuscript File	5784-Review.doc
Answering Reviewers	5784-Answering reviewers.pdf
Copyright License Agreement	5784-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5784-Language certificate.pdf
Peer-review Report	5784-Peer reviews.pdf
Scientific Editor Work List	5784-Scientific editor work list.doc