Publication Name	World Journal of Gastroenterology
Manuscript ID	5788
Country	China

Received	2013-09-25 22:25
Peer-Review Started	2013-09-27 12:22
To Make the First Decision	2013-10-14 21:11
Return for Revision	2013-10-16 15:38
Revised	2013-11-04 16:02
Second Decision	2013-11-13 12:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-13 15:11
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-26 21:46
Typeset the Manuscript	2013-12-21 19:00
Publish the Manuscript Online	2014-01-14 20:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Cystatin C is a biomarker for predicting acute kidney injury in patients with acute-on-chronic liver failure
Manuscript Source	Invited Manuscript
All Author List	Zhi-Hong Wan, Jian-Jun Wang, Shao-Li You, Hong-Ling Liu, Bing Zhu, Hong Zang, Chen Li, Jing Chen and Shao-Jie Xin
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Municipal Science and Technology Commission Z131107002213018 12th Five-Year National Science and Technology Major Project for Infectious Diseases (partially) 2012ZX10002004-005
Corresponding Author	Shao-Jie Xin, MD, Professor, Director, Liver Failure Treatment and Research Center, Beijing 302 Hospital, 100 Xisihuan Middle Road, Beijing 100039, China. xinshaojie302@163.com
Key Words	Acute-on-chronic liver failure; Cystatin C; Creatinine; Acute kidney injury; Prediction
Core Tip	Severe renal dysfunction often occurs in patients with acute-on-chronic liver failure (ACLF) due to circulatory abnormalities and inflammation. New biomarkers with higher reliability and specificity for monitoring renal function are required. Fifty-six patients with ACLF and normal serum creatinine (Cr) were enrolled. Our results showed that patients who developed acute kidney injury during hospitalization had significantly higher basal serum cystatin C (CysC) levels. CysC-based estimated glomerular filtration rate more accurately represented renal function in ACLF patients. CysC can be used as an early biomarker for detection of renal dysfunction in patients with ACLF before any increase in serum Cr is detected.
Publish Date	2014-01-14 20:11
Citation	Wan ZH, Wang JJ, You SL, Liu HL, Zhu B, Zang H, Li C, Chen J, Xin SJ. Cystatin C is a biomarker for predicting acute kidney injury in patients with acute-on-chronic liver failure. World J Gastroenterol 2013; 19(48): 9432-9438
URL	http://www.wjgnet.com/1007-9327/full/v19/i48/9432.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i48.9432

Full Article (PDF)	WJG-19-9432.pdf
Manuscript File	5788-Review.doc
Answering Reviewers	5788-Answering reviewers.pdf
Copyright License Agreement	5788-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5788-Language certificate.PDF
Peer-review Report	5788-Peer reviews.pdf
Scientific Editor Work List	5788-Scientific editor work list.doc